Gene Symbol | MAP4K3 |
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Entrez Gene | 8491 |
Alt Symbol | GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1 |
Species | Human |
Gene Type | protein-coding |
Description | mitogen-activated protein kinase kinase kinase kinase 3 |
Other Description | MAPK/ERK kinase kinase kinase 3|MEK kinase kinase 3|germinal center kinase-like kinase|germinal center kinase-related protein kinase |
Swissprots | Q9Y6R5 Q9UDM5 Q8IVH8 Q8IVH7 Q6IQ39 |
Accessions | AAF19240 AAN75849 AAN75850 AAY14734 EAX00346 EAX00347 Q8IVH8 AK021553 BAG51037 AK291467 BAF84156 AK299889 BAG61735 AK314487 AK316144 BAH14515 BC060880 BC071579 AAH71579 DA409370 EU832785 ACE87796 GQ129258 ACT64392 XR_939730 NM_001270425 NP_001257354 NM_003618 NP_003609 |
Function | May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}. |
Tissue Specificity | Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. {ECO:0000269|PubMed:9275185}. |
Top Pathways | MAPK signaling pathway |
GLK CRISPR/Cas9 KO Plasmid (h) - sc-406054 from Santa Cruz Biotechnology
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GLK HDR Plasmid (h) - sc-406054-HDR from Santa Cruz Biotechnology
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GLK Double Nickase Plasmid (h) - sc-406054-NIC from Santa Cruz Biotechnology
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GLK Double Nickase Plasmid (h2) - sc-406054-NIC-2 from Santa Cruz Biotechnology
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GLK CRISPR Activation Plasmid (h) - sc-406054-ACT from Santa Cruz Biotechnology
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GLK CRISPR Activation Plasmid (h2) - sc-406054-ACT-2 from Santa Cruz Biotechnology
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GLK Lentiviral Activation Particles (h) - sc-406054-LAC from Santa Cruz Biotechnology
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GLK Lentiviral Activation Particles (h2) - sc-406054-LAC-2 from Santa Cruz Biotechnology
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GLK siRNA (h) - sc-39241 from Santa Cruz Biotechnology
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GLK shRNA Plasmid (h) - sc-39241-SH from Santa Cruz Biotechnology
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GLK shRNA (h) Lentiviral Particles - sc-39241-V from Santa Cruz Biotechnology
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MAP4K3 RNAi - H00008491-R02 from Novus Biologicals
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MISSION® esiRNA - EHU071911 from Sigma-Aldrich
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MISSION® siRNA - SIHK1174 from Sigma-Aldrich
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MISSION® siRNA - SIHK1175 from Sigma-Aldrich
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MISSION® siRNA - SIHK1176 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2165 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2165 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09093 from Sigma-Aldrich
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MAP4K3 siRNA (Human) - CRH5566 from Cohesion Biosciences
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shRNA set against Human MAP4K3 (NM_003618.3) - SHH337823 from Creative biogene
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MAP4K3 shRNA Plasmid (Human) - CHH5566 from Cohesion Biosciences
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MAP4K3 miRNA 3'UTR clone - MiUTR3H-07208 from Creative biogene
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