| Gene Symbol |
KIF16B
|
| Entrez Gene |
55614
|
| Alt Symbol |
C20orf23, KISC20ORF, SNX23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinesin family member 16B
|
| Other Description |
kinesin motor protein|kinesin-like protein KIF16B|sorting nexin 23
|
| Swissprots |
B1AKG3 Q9BQM5 Q8IYU0 B1AKT7 Q2TBF5 Q9BQJ8 Q9H5U0 Q5HYC0 C9JSM8 C9JDN5 Q86VL9 A6NKJ9 C9JWJ7 Q5HYK1 Q5JWW3 Q9BQM0 C9JI52 Q9HCI2 Q86YS5 Q9NXN9 Q9BQM1 A7E2A8 Q96L93 Q5TFK5
|
| Accessions |
EAX10287 EAX10288 EAX10289 EAX10290 Q96L93 AB046810 BAB13416 AK000142 BAA90971 AK026698 BAB15530 AK095322 AK307399 AY044654 AAK98768 AY166853 AAO17292 BC015384 BC034984 AAH34984 BC050577 BC110317 AAI10318 BC150261 AAI50262 BQ067573 BX647572 CAI46105 BX648426 CAI46266 XM_005260750 XP_005260807 XM_005260751 XP_005260808 XM_005260752 XP_005260809 XM_005260753 XP_005260810 XM_005260754 XP_005260811 XM_005260755 XP_005260812 XM_006723588 XP_006723651 XM_011529288 XP_011527590 NM_001199865 NP_001186794 NM_001199866 NP_001186795 NM_024704 NP_078980
|
| Function |
Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. {ECO:0000269|PubMed:15882625}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000305}. Early endosome membrane. Note=It is unclear whether association with endosomes is mediated via phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding or via its interaction with RAB14.
|
| Tissue Specificity |
Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). {ECO:0000269|PubMed:15882625}.
|