NOTCH1

Gene Symbol NOTCH1
Entrez Gene 4851
Alt Symbol AOS5, AOVD1, TAN1, hN1
Species Human
Gene Type protein-coding
Description notch 1
Other Description Notch homolog 1, translocation-associated|neurogenic locus notch homolog protein 1|translocation-associated notch protein TAN-1
Swissprots P46531 Q59ED8 Q5SXM3
Accessions AFA51166 AFA51167 AFD02281 AFD64628 AHH85782 AHJ25884 CBX47648 CCQ43558 EAW88241 P46531 AB209873 BAD93110 AF308602 AAG33848 AK000012 BAA90883 BC013208 BC039147 BC046127 BC049843 BC063597 CN431067 CR457221 CAG33502 DA324222 M73980 AAA60614 XM_011518717 XP_011517019 NM_017617 NP_060087
Function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
Top Pathways Notch signaling pathway, Prion diseases, MicroRNAs in cancer, Dorso-ventral axis formation

NOTCH1 293 Cell Lysate - 402270 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg
Species Drosophila

Notch-1 Overexpression Lysate (Native) - NBL1-13725 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg

NOTCH1 Over-expression Lysate Product - GWB-D5B1C8 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

Panoply™ Human NOTCH1 Knockdown Stable Cell Line - CSC-DC010514 from Creative biogene

Category Cell Line
Species Human

Human NOTCH1 Knockout Cell Line-HeLa - CSC-RT0701 from Creative biogene

Category Cell Line
Species Human

NOTCH1 KO Cell Lysate-HeLa - CLKO-0206 from Creative biogene

Category Cell Lysate
Search more