NOTCH1
| Gene Symbol | NOTCH1 |
|---|---|
| Entrez Gene | 4851 |
| Alt Symbol | AOS5, AOVD1, TAN1, hN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | notch 1 |
| Other Description | Notch homolog 1, translocation-associated|neurogenic locus notch homolog protein 1|translocation-associated notch protein TAN-1 |
| Swissprots | P46531 Q59ED8 Q5SXM3 |
| Accessions | AFA51166 AFA51167 AFD02281 AFD64628 AHH85782 AHJ25884 CBX47648 CCQ43558 EAW88241 P46531 AB209873 BAD93110 AF308602 AAG33848 AK000012 BAA90883 BC013208 BC039147 BC046127 BC049843 BC063597 CN431067 CR457221 CAG33502 DA324222 M73980 AAA60614 XM_011518717 XP_011517019 NM_017617 NP_060087 |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. |
| Top Pathways | Notch signaling pathway, Prion diseases, MicroRNAs in cancer, Dorso-ventral axis formation |
Human activated Notch1 peptide - ab730 from Abcam
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Human activated Notch1 peptide - ab93067 from Abcam
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Human Notch1 peptide - ab68580 from Abcam
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Human Notch1 protein fragment - ab114178 from Abcam
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NOTCH1 Antibody Blocking Peptide - LS-E14184 from LifeSpan Bioscience
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NOTCH1 Antibody Blocking Peptide - LS-E26418 from LifeSpan Bioscience
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Recombinant Human Notch-1 Protein - H00004851-Q01 from Novus Biologicals
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Notch-1 Peptide - NBP1-96995 from Novus Biologicals
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Notch-1 Blocking Peptide - NB300-251PEP from Novus Biologicals
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Recombinant Human Notch-1 Fc Chimera, CF - 3647-TK-050 from R&D Systems
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Notch 1 Blocking Peptide - 33R-10970 from Fitzgerald
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Notch 1 Blocking Peptide - 33R-10562 from Fitzgerald
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NOTCH1 Blocking Peptide - 33R-2456 from Fitzgerald
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NOTCH1 - H00004851-Q01-10 from Acris Antibodies
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NOTCH1 - H00004851-Q01-25 from Acris Antibodies
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NOTCH1 Control Peptide - R1556CP from Acris Antibodies
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NOTCH1 Control Peptide - R1557CP from Acris Antibodies
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Recombinant Human NOTCH1 - NOTCH1-29727TH from Creative Biomart
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Recombinant Human NOTCH1 - NOTCH1-384H from Creative Biomart
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NOTCH 1 (Human specific) Peptide - 000-000-407 from Rockland Immunochemicals Inc
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NOTCH 1 (intra) (Human specific) Peptide - 000-000-405 from Rockland Immunochemicals Inc
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NOTCH1 Blocking Peptide - CBP4126 from Cohesion Biosciences
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Cleaved-Notch 1 (V1754) Peptide - BS7018 P from Bioworld Technology
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Notch1 - pro10364 from Covalab
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Recombinant Human Neurogenic locus notch homolog protein 1(NOTCH1) ,partial - CSB-YP015949HU CSB-EP015949HU CSB-BP015949HU CSB-MP015949HU from Cusabio
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