| Gene Symbol | SEC14L2 |
|---|---|
| Entrez Gene | 23541 |
| Alt Symbol | C22orf6, SPF, TAP, TAP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SEC14-like 2 (S. cerevisiae) |
| Other Description | SEC14-like protein 2|alpha-tocopherol-associated protein|squalene transfer protein|supernatant protein factor|tocopherol-associated protein |
| Swissprots | Q53EQ2 F5H3U4 Q9ULN4 Q6PD61 B7Z8Q1 O76054 |
| Accessions | AAF19256 EAW59885 EAW59886 EAW59887 EAW59888 O76054 AA610131 AB033012 BAA86500 AK056163 AK091402 BAG52350 AK092576 AK223587 BAD97307 AK296540 BAH12384 AK303751 BAH14037 AK314390 BAG37015 AL096881 CAB51405 AY203959 AAP34482 AY927430 AY927434 AY927435 AY927436 AY927437 AY927438 AY927439 AY927441 BC048337 BC058915 AAH58915 BM680990 BU734336 CR456571 CAG30457 CU013170 CAK54601 CU013458 CAK54900 DC375707 NM_001204204 NP_001191133 NM_001291932 NP_001278861 NM_012429 NP_036561 NM_033382 NP_203740 |
| Function | Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol. |
| Tissue Specificity | Widely expressed. Strong expression in liver, brain and prostate. {ECO:0000269|PubMed:10829015}. |