| Gene Symbol |
GULP1
|
| Entrez Gene |
51454
|
| Alt Symbol |
CED-6, CED6, GULP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GULP, engulfment adaptor PTB domain containing 1
|
| Other Description |
PTB domain adapter protein CED-6|PTB domain adaptor protein CED-6|PTB domain-containing engulfment adapter protein 1|cell death protein 6 homolog|engulfment adapter protein
|
| Swissprots |
Q53PC1 B4DQ40 Q9UBP9 D3DPH1 B2RB51 Q53RF3 Q9BVL3 B8ZZ72 E9PB86
|
| Accessions |
AAX93242 AAY24122 CAC07438 EAX10913 EAX10914 EAX10915 EAX10916 EAX10917 Q9UBP9 AB209890 BAD93127 AF075014 AF191771 AAF18975 AF200715 AAF08006 AK023668 BAG51214 AK055718 AK130507 AK298626 BAG60802 AK314498 BAG37098 AL080142 AW149992 BC001103 AAH01103 BC068525 CD627760 DA392794 XM_006712580 XP_006712643 XM_006712581 XP_006712644 XM_006712582 XP_006712645 XM_006712583 XP_006712646 XM_006712584 XP_006712647 XM_006712585 XP_006712648 XM_006712589 XP_006712652 XM_006712590 XP_006712653 XM_011511327 XP_011509629 XM_011511328 XP_011509630 XM_011511329 XP_011509631 XM_011511330 XP_011509632 XM_011511331 XP_011509633 XM_011511332 XP_011509634 XM_011511333 XP_011509635 XM_011511334 XP_011509636 XM_011511335 XP_011509637 NM_001252668 NP_001239597 NM_001252669 NP_001239598 NM_016315 NP_057399 NR_045562 NR_045563
|
| Function |
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. {ECO:0000269|PubMed:10574763, ECO:0000269|PubMed:10574771, ECO:0000269|PubMed:16497666, ECO:0000269|PubMed:17398097}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16497666}. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.
|
| Tissue Specificity |
Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. {ECO:0000269|PubMed:10574763}.
|