KMT2C

Gene Symbol	KMT2C
Entrez Gene	58508
Alt Symbol	HALR, MLL3
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific methyltransferase 2C
Other Description	ALR-like protein\|histone-lysine N-methyltransferase 2C\|histone-lysine N-methyltransferase MLL3\|histone-lysine N-methyltransferase, H3 lysine-4 specific\|homologous to ALR protein\|myeloid/lymphoid or mixed-lineage leukemia protein 3
Swissprots	Q9NR13 Q8NC02 Q8NEZ4 Q9H9P4 Q9UDR7 Q9P222 Q8NDF6
Accessions	AAD45822 AAS00364 Q8NEZ4 AB040939 BAA96030 AF264750 AAF74766 AK022687 AK025553 AK025911 AK075113 BAC11409 AK095628 AL832387 AL833924 CAD38780 AY024361 AAK00583 BC011921 BC151837 AAI51838 BP281562 BU623509 BU685177 BX640742 CAE45854 CD513584 DA266956 XM_005250025 XP_005250082 XM_005250026 XP_005250083 XM_005250027 XP_005250084 XM_005250028 XP_005250085 XM_005250031 XP_005250088 XM_006716077 XP_006716140 XM_006716078 XP_006716141 XM_006716079 XP_006716142 XM_011516450 XP_011514752 XM_011516451 XP_011514753 XM_011516452 XP_011514754 XM_011516453 XP_011514755 XM_011516454 XP_011514756 XM_011516455 XP_011514757 XM_011516456 XP_011514758 XR_428183 NM_170606 NP_733751 NM_021230
Function	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269\|PubMed:17500065}.
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
Top Pathways	Lysine degradation

MLL3 (C-16) - sc-130173 from Santa Cruz Biotechnology

Host	Rabbit
Clonality	Polyclonal

MLL3 (C-16): sc-130173. Western blot analysis of MLL3 expression in 293 whole cell lysate.

MLL3 (Q-20) - sc-67718 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MLL3 (T-19) - sc-67719 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-KMT2C / MLL3 (acetyl K2809) antibody - ab40973 from Abcam

Prices	$242.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

This antibody gave a positive result in ELISA against the immunizing peptide (ab41903, blue). It gave a negative result in ELISA against the non-modified equivalent peptide (ab41904, yellow). This indicates that it is specific for the modified peptide.

Anti-KMT2C / MLL3 antibody - ab71200 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-KMT2C / MLL3 antibody (ab71200) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HEK 293 cell line lysateLysates/proteins at 12.5 µg per lane.SecondaryHRP goat anti-rabbit (H+L) at 1/5000 dilution

Anti-KMT2C / MLL3 antibody - ab32581 from Abcam

Prices	$368.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2C / MLL3 Antibody (aa3478-3493) - LS-C3121 from LifeSpan Bioscience

Prices	$265.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2C / MLL3 Antibody (aa3471-3501, APC) - LS-C279627 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2C / MLL3 Antibody (aa3471-3501, AP) - LS-C279626 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2C / MLL3 Antibody (aa3471-3501, FITC) - LS-C279630 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2C / MLL3 Antibody (aa3471-3501, Azide-free, HRP) - LS-C279631 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2C / MLL3 Antibody (aa3471-3501, Biotin) - LS-C279629 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-KMT2C / MLL3 Antibody (aa3471-3501, PE) - LS-C279632 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

MLL3 Antibody - 45880002 from Novus Biologicals

Prices	$329.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western Blot: MLL3 Antibody [45880002] - analysis of MLL3 in Jurkat cell lysate (30ug/lane) using anti-MLL3 antibody. The primary antibody was used at a dilution of 1:2000 in PBS and incubated for 3 hours at room temperature. Image from verified customer review.

Anti-MLL3 (C-term) antibody produced in rabbit - SAB1300082 from Sigma-Aldrich

Prices	$291.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-MLL3 (C-term) Antibody: <B>Cat. No. SAB1300082</B>: MLL3 in HEK 293 cell line lysates with Anti-MLL3 (C-term) Antibody at 4.0 μg/mL.

Anti-MLL3 (center) antibody produced in rabbit - SAB1300328 from Sigma-Aldrich

Prices	$291.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

MLL3-Antibody-C-term - AP6184a from Abgent, a WuXi AppTec company

Prices	$95.00, $265.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of MLL3 Antibody (C-term) (Cat.#AP6184a) in HEK 293 cell line lysates. MLL3 (arrow) was detected using the purified Pab.

MLL3 antibody - GTX53678 from GeneTex

Host	Rabbit
Clonality	Polyclonal

Anti-MLL3 antibody used in Western blot. GTX53678

MLL3 Antibody - abx032715 from Abbexa

Host	Rabbit
Clonality	Polyclonal

MLL3 (C-term) antibody - AP13149PU-N from Acris Antibodies

Host	Rabbit
Clonality	Polyclonal

Western blot analysis of MLL3 Antibody (C-term) in HEK 293 cell line lysates. MLL3 (arrow) was detected using the purified Pab (1:1000 dilution).

Rabbit Anti-Human MLL3 (C-term) - 102-16667 from RayBiotech

Host	Rabbit

Western blot analysis of MLL3 Antibody (C-term) (Cat# 102-16667) in HEK 293 cell line lysates. MLL3 (arrow) was detected using the purified Pab.

MLL3 antibody (C-term) - STJ49832 from St John's Laboratory Ltd

Host	Rabbit
Clonality	Polyclonal
Clone	RB1921

MLL3 - MBS626263 from MyBioSource

Prices	$490.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

MLL3 antibody - TA590379 from Acris Antibodies

Prices	$325.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

MLL3 - MBS9212130 from MyBioSource

Prices	$155.00, $295.00
Sizes	80 µl, 400 µl
Host	Rabbit
Clonality	Polyclonal
Clone	RB1921

Western blot analysis of MLL3 Antibody (C-term) in HEK 293 cell line lysates. MLL3 (arrow) was detected using the purified Pab.

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