KMT2C

Gene Symbol	KMT2C
Entrez Gene	58508
Alt Symbol	HALR, MLL3
Species	Human
Gene Type	protein-coding
Description	lysine (K)-specific methyltransferase 2C
Other Description	ALR-like protein|histone-lysine N-methyltransferase 2C|histone-lysine N-methyltransferase MLL3|histone-lysine N-methyltransferase, H3 lysine-4 specific|homologous to ALR protein|myeloid/lymphoid or mixed-lineage leukemia protein 3
Swissprots	Q9NR13 Q8NC02 Q8NEZ4 Q9H9P4 Q9UDR7 Q9P222 Q8NDF6
Accessions	AAD45822 AAS00364 Q8NEZ4 AB040939 BAA96030 AF264750 AAF74766 AK022687 AK025553 AK025911 AK075113 BAC11409 AK095628 AL832387 AL833924 CAD38780 AY024361 AAK00583 BC011921 BC151837 AAI51838 BP281562 BU623509 BU685177 BX640742 CAE45854 CD513584 DA266956 XM_005250025 XP_005250082 XM_005250026 XP_005250083 XM_005250027 XP_005250084 XM_005250028 XP_005250085 XM_005250031 XP_005250088 XM_006716077 XP_006716140 XM_006716078 XP_006716141 XM_006716079 XP_006716142 XM_011516450 XP_011514752 XM_011516451 XP_011514753 XM_011516452 XP_011514754 XM_011516453 XP_011514755 XM_011516454 XP_011514756 XM_011516455 XP_011514757 XM_011516456 XP_011514758 XR_428183 NM_170606 NP_733751 NM_021230
Function	Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065}.
Subcellular Location	Nucleus {ECO:0000305}.
Tissue Specificity	Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver.
Top Pathways	Lysine degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human KMT2C / MLL3 (acetyl K2809) peptide - ab41903 from Abcam Category Peptide

Human KMT2C / MLL3 peptide - ab32940 from Abcam Category Peptide

Human KMT2C / MLL3 peptide - ab41904 from Abcam Category Peptide

KMT2C / MLL3 Blocking Peptide - LS-E8115 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MLL3 Peptide - P1792 from Novus Biologicals Category Peptide Species Human

MLL3-Antibody-C-term-Blocking-Peptide - BP6184a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant MLL3 Complex - 31478 from ActiveMotif Prices $395.00, $3,500.00 Sizes 20 µg, 1 mg Source E. coli Species Human

Recombinant Human Histone-lysine N-methyltransferase MLL3(MLL3) ,partial - CSB-YP822778HU CSB-EP822778HU CSB-BP822778HU CSB-MP822778HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human KMT2C Complex, His-tagged - KMT2C-130H from Creative Biomart Category Protein Source E.coli Species Human

MLL3-Antibody-N-term-Blocking-Peptide - BP6184d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL3-Antibody-Center-Blocking-Peptide - BP6184c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL3-Blocking-Peptide-C-term - BP22080b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL3-Blocking-Peptide-N-term - BP22079a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MLL3 Peptide, Human - M34GP09565H from Creative Peptides Category Peptide Source Synthetic. Species Human

MLL3 Recombinant Protein Antigen - NBP2-57730PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Histone-lysine N-methyltransferase MLL3 (MLL3), partial, Recombinant Protein - MBS1387253 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MLL3, Recombinant Protein - MBS515548 from MyBioSource Category Protein Prices $315.00, $425.00 Sizes 5 µg, 10 µg Source Sf9 insect cells using baculovirus Species Human

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