| Gene Symbol |
PTCRA
|
| Entrez Gene |
171558
|
| Alt Symbol |
PT-ALPHA, PTA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pre T-cell antigen receptor alpha
|
| Other Description |
pT-alpha-TCR|pre-T-cell receptor alpha chain
|
| Swissprots |
Q6ISU1 Q5TFZ7
|
| Accessions |
AAC83346 EAX04107 EAX04108 EAX04109 EAX04110 Q6ISU1 AF101436 AAF21890 AF165312 AAF89556 AK130819 BAC85438 AK303523 BAG64551 AK310559 AK312223 BAG35156 AW014894 BC069336 AAH69336 BC100771 AAI00772 BC100772 AAI00773 BC100773 AAI00774 BC100774 AAI00775 BC153829 AAI53830 U36759 AAB06194 U38996 AAB18373 XM_011514316 XP_011512618 XM_011514317 XP_011512619 NM_001243168 NP_001230097 NM_001243169 NP_001230098 NM_001243170 NP_001230099 NM_138296 NP_612153
|
| Function |
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow. {ECO:0000269|PubMed:8618853, ECO:0000269|PubMed:8760805}.
|
| Top Pathways |
Notch signaling pathway, Transcriptional misregulation in cancer
|