| Gene Symbol |
HSPB11
|
| Entrez Gene |
51668
|
| Alt Symbol |
C1orf41, HSPCO34, IFT25, PP25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heat shock protein family B (small), member 11
|
| Other Description |
heat shock protein beta-11|intraflagellar transport 25 homolog|intraflagellar transport protein 25 homolog|placental protein 25
|
| Swissprots |
Q9Y547 A6NG57 Q9Y684 D3DQ45
|
| Accessions |
EAX06717 EAX06718 EAX06719 Q9Y547 AF100747 AAD43011 AF416725 AAQ03618 AF417114 AAQ03994 AK225916 BC005245 AAH05245 BC045699 HQ447962 ADQ32445 L32869 X79302 XM_005270942 XP_005270999 NM_016126 NP_057210
|
| Function |
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell projection, cilium {ECO:0000250}.
|
| Tissue Specificity |
Detected in placenta. {ECO:0000269|PubMed:2018407}.
|