Gene Symbol | HSPB11 |
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Entrez Gene | 51668 |
Alt Symbol | C1orf41, HSPCO34, IFT25, PP25 |
Species | Human |
Gene Type | protein-coding |
Description | heat shock protein family B (small), member 11 |
Other Description | heat shock protein beta-11|intraflagellar transport 25 homolog|intraflagellar transport protein 25 homolog|placental protein 25 |
Swissprots | Q9Y547 A6NG57 Q9Y684 D3DQ45 |
Accessions | EAX06717 EAX06718 EAX06719 Q9Y547 AF100747 AAD43011 AF416725 AAQ03618 AF417114 AAQ03994 AK225916 BC005245 AAH05245 BC045699 HQ447962 ADQ32445 L32869 X79302 XM_005270942 XP_005270999 NM_016126 NP_057210 |
Function | Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity). {ECO:0000250}. |
Subcellular Location | Cell projection, cilium {ECO:0000250}. |
Tissue Specificity | Detected in placenta. {ECO:0000269|PubMed:2018407}. |
HSPB11 CRISPR/Cas9 KO Plasmid (h) - sc-417276 from Santa Cruz Biotechnology
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HSPB11 HDR Plasmid (h) - sc-417276-HDR from Santa Cruz Biotechnology
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HSPB11 Double Nickase Plasmid (h) - sc-417276-NIC from Santa Cruz Biotechnology
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HSPB11 Double Nickase Plasmid (h2) - sc-417276-NIC-2 from Santa Cruz Biotechnology
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HSPB11 CRISPR Activation Plasmid (h) - sc-417276-ACT from Santa Cruz Biotechnology
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HSPB11 CRISPR Activation Plasmid (h2) - sc-417276-ACT-2 from Santa Cruz Biotechnology
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HSPB11 Lentiviral Activation Particles (h) - sc-417276-LAC from Santa Cruz Biotechnology
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HSPB11 Lentiviral Activation Particles (h2) - sc-417276-LAC-2 from Santa Cruz Biotechnology
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HSPB11 siRNA (h) - sc-88107 from Santa Cruz Biotechnology
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HSPB11 shRNA Plasmid (h) - sc-88107-SH from Santa Cruz Biotechnology
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HSPB11 shRNA (h) Lentiviral Particles - sc-88107-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU085301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10371 from Sigma-Aldrich
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HSPB11 siRNA (Human) - CRH9893 from Cohesion Biosciences
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HSPB11 - MBS8210483 from MyBioSource
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shRNA set against Human HSPB11 (NM_016126.2) - SHH315657 from Creative biogene
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Human HSPB11 siRNA - orb270395 from Biorbyt
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HSPB11 shRNA Plasmid (Human) - CHH9893 from Cohesion Biosciences
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HSPB11 miRNA 3'UTR clone - MiUTR1H-01258 from Creative biogene
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