Gene Symbol | GATB |
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Entrez Gene | 5188 |
Alt Symbol | HSPC199, PET112, PET112L |
Species | Human |
Gene Type | protein-coding |
Description | glutamyl-tRNA(Gln) amidotransferase, subunit B |
Other Description | PET112 homolog|cytochrome c oxidase assembly factor PET112 homolog|cytochrome oxidase assembly factor PET112 homolog|glu-AdT subunit B|glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial |
Swissprots | Q9P0S6 Q9Y2B8 Q53GP4 Q4W5M8 O75879 |
Accessions | AAY40897 EAX04981 EAX04982 EAX04983 O75879 AB019410 AF026851 AAD08640 AF151033 AAF36119 AK124986 AK222887 BAD96607 AK225241 AK303461 BAG64504 AK312957 BAG35796 BC067838 BC130348 AAI30349 BC136547 AAI36548 BP348031 BX537555 CAH56162 XM_005263063 XP_005263120 XM_011532026 XP_011530328 NM_004564 NP_004555 |
Function | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000269|PubMed:19805282}. |
Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03147, ECO:0000269|PubMed:9878253}. |
Tissue Specificity | Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle and heart. {ECO:0000269|PubMed:9878253}. |
Top Pathways | Aminoacyl-tRNA biosynthesis |
PET112L CRISPR/Cas9 KO Plasmid (h) - sc-410928 from Santa Cruz Biotechnology
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PET112L HDR Plasmid (h) - sc-410928-HDR from Santa Cruz Biotechnology
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PET112L Double Nickase Plasmid (h) - sc-410928-NIC from Santa Cruz Biotechnology
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PET112L Double Nickase Plasmid (h2) - sc-410928-NIC-2 from Santa Cruz Biotechnology
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PET112L CRISPR Activation Plasmid (h) - sc-410928-ACT from Santa Cruz Biotechnology
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PET112L CRISPR Activation Plasmid (h2) - sc-410928-ACT-2 from Santa Cruz Biotechnology
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PET112L Lentiviral Activation Particles (h) - sc-410928-LAC from Santa Cruz Biotechnology
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PET112L Lentiviral Activation Particles (h2) - sc-410928-LAC-2 from Santa Cruz Biotechnology
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PET112L siRNA (h) - sc-76108 from Santa Cruz Biotechnology
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PET112L shRNA Plasmid (h) - sc-76108-SH from Santa Cruz Biotechnology
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PET112L shRNA (h) Lentiviral Particles - sc-76108-V from Santa Cruz Biotechnology
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PET112L RNAi - H00005188-R01 from Novus Biologicals
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MISSION® esiRNA - EHU020441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16627 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16627 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02454 from Sigma-Aldrich
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PET112 siRNA (Human) - CRH3460 from Cohesion Biosciences
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shRNA set against Human PET112 (NM_004564.2) - SHH373600 from Creative biogene
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PET112 shRNA Plasmid (Human) - CHH3460 from Cohesion Biosciences
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PET112 miRNA 3'UTR clone - MiUTR3H-06151 from Creative biogene
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