| Gene Symbol |
TMX1
|
| Entrez Gene |
81542
|
| Alt Symbol |
PDIA11, TMX, TXNDC, TXNDC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thioredoxin-related transmembrane protein 1
|
| Other Description |
protein disulfide isomerase family A, member 11|thioredoxin domain containing 1|thioredoxin domain-containing protein 1|transmembrane Trx-related protein
|
| Swissprots |
Q8N487 B2R7A4 Q9H3N1 Q9Y4T6 Q8NBN5
|
| Accessions |
EAW65678 EAW65679 Q9H3N1 AB048246 BAB20629 AK075395 BAC11593 AK302416 BAH13701 AK303134 BAG64239 AK312905 BAG35751 AL080080 CAB45700 AY358640 AAQ89003 BC016769 BC032834 BC036460 AAH36460 BC050366 BC056874 AAH56874 BU754378 DA203669 DQ891674 ABM82600 DQ894860 ABM85786 NM_030755 NP_110382
|
| Function |
May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly found in the endoplasmic reticulum. {ECO:0000269|PubMed:11152479}.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in kidney, liver, placenta and lung.
|
![Western Blot: TXNDC Overexpression Lysate (Adult Normal) [NBL1-17463] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TXNDC.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2145_TXNDC%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17463-img0002.jpg)