Gene Symbol | Pfn4 |
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Entrez Gene | 382562 |
Alt Symbol | 2900024P18Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | profilin family, member 4 |
Other Description | profilin IV|profilin-4 |
Swissprots | Q9D6I3 |
Accessions | EDL01356 EDL01357 Q9D6I3 AK013595 BAB28919 AY495949 AAS75143 BC094614 BC116888 AAI16889 BC116890 AAI16891 XM_006515138 XP_006515201 XM_006515139 XP_006515202 XM_006515140 XP_006515203 XM_006515141 XP_006515204 NM_028376 NP_082652 |
Function | Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin, contrary to other family members (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. |
Tissue Specificity | Detected in testis (at protein level). {ECO:0000269|PubMed:15591451}. |
Top Pathways | Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton |
Profilin-4 CRISPR/Cas9 KO Plasmid (m) - sc-436397 from Santa Cruz Biotechnology
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Profilin-4 HDR Plasmid (m) - sc-436397-HDR from Santa Cruz Biotechnology
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Profilin-4 Double Nickase Plasmid (m) - sc-436397-NIC from Santa Cruz Biotechnology
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Profilin-4 Double Nickase Plasmid (m2) - sc-436397-NIC-2 from Santa Cruz Biotechnology
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Profilin-4 CRISPR Activation Plasmid (m) - sc-436397-ACT from Santa Cruz Biotechnology
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Profilin-4 CRISPR Activation Plasmid (m2) - sc-436397-ACT-2 from Santa Cruz Biotechnology
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Profilin-4 Lentiviral Activation Particles (m) - sc-436397-LAC from Santa Cruz Biotechnology
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Profilin-4 Lentiviral Activation Particles (m2) - sc-436397-LAC-2 from Santa Cruz Biotechnology
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Profilin-4 siRNA (m) - sc-152478 from Santa Cruz Biotechnology
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Profilin-4 shRNA Plasmid (m) - sc-152478-SH from Santa Cruz Biotechnology
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Profilin-4 shRNA (m) Lentiviral Particles - sc-152478-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU035811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38588 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38588 from Sigma-Aldrich
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PFN4 siRNA (Mouse) - CRN4928 from Cohesion Biosciences
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shRNA set against Mouse PFN4 (NM_028376.3) - SHH374032 from Creative biogene
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shRNA set against Mouse Pfn4(NM_028376.3) - SHR108114 from Creative biogene
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PFN4 shRNA Plasmid (Mouse) - CHN4928 from Cohesion Biosciences
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PFN4 miRNA 3'UTR clone - MiUTR1M-09132 from Creative biogene
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