| Gene Symbol |
CTNNA2
|
| Entrez Gene |
1496
|
| Alt Symbol |
CAP-R, CAPR, CT114, CTNR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
catenin (cadherin-associated protein), alpha 2
|
| Other Description |
alpha N-catenin|alpha-N-catenin|alpha-catenin-related protein|cadherin-associated protein, related|cancer/testis antigen 114|catenin alpha-2
|
| Swissprots |
B7Z2W7 Q53TM8 B3KXE5 Q53R26 Q53R33 Q4ZFW1 Q7Z3L1 B7Z898 Q7Z3Y0 B7Z352 Q53T67 P26232 Q53T71
|
| Accessions |
AAX88946 AAX93241 AAY14758 AAY14763 AAY15008 AAY15073 EAW99563 EAW99564 EAW99565 P26232 AK127226 BAG54457 AK294362 BAH11745 AK295181 BAH12003 AK295493 BAH12088 AK303035 BAH13884 AL708938 BC040458 AAH40458 BC052996 AAH52996 BI599815 BX537769 CAD97832 BX648368 DA313393 DC341423 HQ589336 AEF32484 M94151 AAA58407 XM_006711949 XP_006712012 XM_011532555 XP_011530857 XM_011532556 XP_011530858 XM_011532557 XP_011530859 NM_001164883 NP_001158355 NM_001282597 NP_001269526 NM_001282598 NP_001269527 NM_001282599 NP_001269528 NM_001282600 NP_001269529 NM_004389 NP_004380
|
| Function |
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Recruited to the nucleus upon ZNF639 overexpression.
|
| Top Pathways |
Adherens junction, Tight junction, Leukocyte transendothelial migration, Endometrial cancer, Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|
![Western Blot: Catenin alpha 2 Overexpression Lysate (Adult Normal) [NBL1-09576] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Catenin alpha 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12008_Catenin%2520alpha%25202%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09576-img0002.jpg)