AHRR

Gene Symbol	AHRR
Entrez Gene	57491
Alt Symbol	AHH, AHHR, bHLHe77
Species	Human
Gene Type	protein-coding
Description	aryl-hydrocarbon receptor repressor
Other Description	ahR repressor|aryl hydrocarbon hydroxylase regulator|aryl hydrocarbon receptor repressor|class E basic helix-loop-helix protein 77|dioxin receptor repressor
Swissprots	A7MBN5 Q9ULI6 Q9HAZ3 D6RAZ1 A9YTQ3
Accessions	A9YTQ3 AAG33381 EAW50992 AB033060 BAA86548 AK090508 AK127977 AK314472 BC035358 BC121047 BC121048 BC151852 AAI51853 BC152406 AAI52407 BC160162 AAI60162 BM682431 BU738250 BX400426 DA051156 DA863025 EU293605 ABX89616 NM_001242412 NP_001229341 NM_020731 NP_065782
Function	Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17980155}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
Tissue Specificity	Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. {ECO:0000269|PubMed:11835227, ECO:0000269|PubMed:14672759, ECO:0000269|PubMed:18172554}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AHRR (D-14) - sc-138745 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

AHRR (H-300) - sc-367365 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-AHRR antibody - ab108518 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AHRR antibody - ab85666 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AHRR antibody - ab43199 from Abcam Prices $372.00 Sizes 100 µl Host Mouse Clonality Polyclonal

Anti-AHRR / AhR Repressor Antibody - LS-C178421 from LifeSpan Bioscience Prices $255.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AHRR / AhR Repressor Antibody (aa647-696) - LS-C101764 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-AHRR / AhR Repressor Antibody (aa351-400) - LS-C116035 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

AHRR Antibody - NBP1-89194 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AHRR Antibody - H00057491-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-AHRR antibody produced in rabbit - SAB2100078 from Sigma-Aldrich Prices $347.50, $347.50 Sizes 50 µg, 100 µl Host Rabbit Clonality Polyclonal

Anti-AHRR antibody produced in rabbit - HPA019614 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-AHRR antibody produced in rabbit - HPA021483 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AHRR antibody - middle region (ARP39438_P050) - ARP39438_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AHRR Antibody (Phospho-Ser36) (OAAF00136) - OAAF00136 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-AHRR Antibody - AC11-0212 from Abcore Prices $325.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-AHRR Antibody - AC11-0213 from Abcore Prices $325.00 Sizes 100 µg Host Goat Clonality Polyclonal

Ah receptor repressor (AhRR) antibody - H00057491-A01 from Acris Antibodies Prices $300.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Ah receptor repressor (AhRR) antibody - H00057491-B01P from Acris Antibodies Prices $1,530.00 Sizes 500 µg Host Mouse Clonality Polyclonal

Ah receptor repressor (AhRR) antibody - H00057491-M01 from Acris Antibodies Prices $360.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5G11

AHRR Antibody - 25-513 from ProSci Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Dioxin, Monoclonal Antibody - MBS830358 from MyBioSource Prices $260.00 Sizes 1 mg Host Mouse Clonality Monoclonal Clone F697A3-3-1

AHRR Antibody - 37416 from Signalway Antibody Prices $279.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AHRR Antibody - GWB-MN075C from Genway Biotech Prices $368.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

AHRR, Polyclonal Antibody - MBS854940 from MyBioSource Prices $290.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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