| Gene Symbol |
AHRR
|
| Entrez Gene |
57491
|
| Alt Symbol |
AHH, AHHR, bHLHe77
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aryl-hydrocarbon receptor repressor
|
| Other Description |
ahR repressor|aryl hydrocarbon hydroxylase regulator|aryl hydrocarbon receptor repressor|class E basic helix-loop-helix protein 77|dioxin receptor repressor
|
| Swissprots |
A7MBN5 Q9ULI6 Q9HAZ3 D6RAZ1 A9YTQ3
|
| Accessions |
A9YTQ3 AAG33381 EAW50992 AB033060 BAA86548 AK090508 AK127977 AK314472 BC035358 BC121047 BC121048 BC151852 AAI51853 BC152406 AAI52407 BC160162 AAI60162 BM682431 BU738250 BX400426 DA051156 DA863025 EU293605 ABX89616 NM_001242412 NP_001229341 NM_020731 NP_065782
|
| Function |
Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17980155}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
|
| Tissue Specificity |
Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. {ECO:0000269|PubMed:11835227, ECO:0000269|PubMed:14672759, ECO:0000269|PubMed:18172554}.
|