Gene Symbol | PIGX |
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Entrez Gene | 54965 |
Alt Symbol | PIG-X |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol glycan anchor biosynthesis, class X |
Other Description | GPI-mannosyltransferase subunit|phosphatidylinositol-glycan biosynthesis class X protein |
Swissprots | Q9NWZ2 Q8TBF5 |
Accessions | EAW53637 EAW53638 EAW53640 Q8TBF5 AA879458 AK000529 BAA91233 AK294340 BAG57610 BC022542 AAH22542 BG715890 BQ130655 BU740645 CN404010 HQ447204 ADQ31691 NM_001166304 NP_001159776 NM_017861 NP_060331 |
Function | Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase PIGM (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
PIG-X CRISPR/Cas9 KO Plasmid (h) - sc-412398 from Santa Cruz Biotechnology
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PIG-X HDR Plasmid (h) - sc-412398-HDR from Santa Cruz Biotechnology
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PIG-X Double Nickase Plasmid (h) - sc-412398-NIC from Santa Cruz Biotechnology
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PIG-X Double Nickase Plasmid (h2) - sc-412398-NIC-2 from Santa Cruz Biotechnology
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PIG-X CRISPR Activation Plasmid (h) - sc-412398-ACT from Santa Cruz Biotechnology
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PIG-X CRISPR Activation Plasmid (h2) - sc-412398-ACT-2 from Santa Cruz Biotechnology
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PIG-X Lentiviral Activation Particles (h) - sc-412398-LAC from Santa Cruz Biotechnology
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PIG-X Lentiviral Activation Particles (h2) - sc-412398-LAC-2 from Santa Cruz Biotechnology
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PIG-X siRNA (h) - sc-78258 from Santa Cruz Biotechnology
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PIG-X shRNA Plasmid (h) - sc-78258-SH from Santa Cruz Biotechnology
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PIG-X shRNA (h) Lentiviral Particles - sc-78258-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU090241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16801 from Sigma-Aldrich
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PIGX siRNA (Human) - CRJ0365 from Cohesion Biosciences
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shRNA set against Human PIGX (NM_017861.3) - SHH375576 from Creative biogene
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Human PIGX siRNA - orb270866 from Biorbyt
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PIGX shRNA Plasmid (Human) - CHJ0365 from Cohesion Biosciences
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PIGX miRNA 3'UTR clone - MiUTR4H-TG06692 from Creative biogene
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