Gene Symbol |
LARP7
|
Entrez Gene |
51574
|
Alt Symbol |
ALAZS, HDCMA18P, PIP7S
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
La ribonucleoprotein domain family, member 7
|
Other Description |
P-TEFb-interaction protein for 7SK stability|la-related protein 7
|
Swissprots |
Q9Y3Z8 Q3B7A9 B2ZHN6 Q9P1S7 Q4G0J3
|
Accessions |
EAX06282 EAX06283 EAX06284 EAX06285 Q4G0J3 AF068284 AAF65503 AI652351 AK000274 AK225900 AL049996 CAB43230 BC006981 AAH06981 BC066945 AAH66945 BC107709 AAI07710 BM979591 BX647100 CA314598 CN346208 DB270203 EU667388 ACD13786 NM_001267039 NP_001253968 NM_015454 NP_056269 NM_016648 NP_057732 NR_049768
|
Function |
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. {ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18483487}.
|
Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:18483487}.
|