Gene Symbol | LARP7 |
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Entrez Gene | 51574 |
Alt Symbol | ALAZS, HDCMA18P, PIP7S |
Species | Human |
Gene Type | protein-coding |
Description | La ribonucleoprotein domain family, member 7 |
Other Description | P-TEFb-interaction protein for 7SK stability|la-related protein 7 |
Swissprots | Q9Y3Z8 Q3B7A9 B2ZHN6 Q9P1S7 Q4G0J3 |
Accessions | EAX06282 EAX06283 EAX06284 EAX06285 Q4G0J3 AF068284 AAF65503 AI652351 AK000274 AK225900 AL049996 CAB43230 BC006981 AAH06981 BC066945 AAH66945 BC107709 AAI07710 BM979591 BX647100 CA314598 CN346208 DB270203 EU667388 ACD13786 NM_001267039 NP_001253968 NM_015454 NP_056269 NM_016648 NP_057732 NR_049768 |
Function | Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. {ECO:0000269|PubMed:18249148, ECO:0000269|PubMed:18483487}. |
Subcellular Location | Nucleus, nucleoplasm {ECO:0000269|PubMed:18483487}. |
LARP7 CRISPR/Cas9 KO Plasmid (h) - sc-404522 from Santa Cruz Biotechnology
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LARP7 HDR Plasmid (h) - sc-404522-HDR from Santa Cruz Biotechnology
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LARP7 Double Nickase Plasmid (h) - sc-404522-NIC from Santa Cruz Biotechnology
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LARP7 Double Nickase Plasmid (h2) - sc-404522-NIC-2 from Santa Cruz Biotechnology
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LARP7 CRISPR Activation Plasmid (h) - sc-404522-ACT from Santa Cruz Biotechnology
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LARP7 CRISPR Activation Plasmid (h2) - sc-404522-ACT-2 from Santa Cruz Biotechnology
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LARP7 Lentiviral Activation Particles (h) - sc-404522-LAC from Santa Cruz Biotechnology
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LARP7 Lentiviral Activation Particles (h2) - sc-404522-LAC-2 from Santa Cruz Biotechnology
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LARP7 siRNA (h) - sc-89099 from Santa Cruz Biotechnology
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LARP7 shRNA Plasmid (h) - sc-89099-SH from Santa Cruz Biotechnology
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LARP7 shRNA (h) Lentiviral Particles - sc-89099-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11555 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11555 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01644 from Sigma-Aldrich
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LARP7 siRNA (Human) - CRH9841 from Cohesion Biosciences
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shRNA set against Human LARP7 (NM_016648.3) - SHH328551 from Creative biogene
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Human LARP7 siRNA - orb270343 from Biorbyt
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LARP7 shRNA Plasmid (Human) - CHH9841 from Cohesion Biosciences
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LARP7 miRNA 3'UTR clone - MiUTR3H-12258 from Creative biogene
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LARP7 miRNA 3'UTR clone - MiUTR3H-12259 from Creative biogene
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