| Gene Symbol |
SLC25A27
|
| Entrez Gene |
9481
|
| Alt Symbol |
UCP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 25, member 27
|
| Other Description |
UCP 4|mitochondrial uncoupling protein 4|uncoupling protein 4
|
| Swissprots |
Q8N518 O95847 Q5VTS9 F5GWR4
|
| Accessions |
EAX04298 EAX04299 O95847 AF110532 AAD16995 AK090871 AK291427 BAF84116 AK295233 BAG58226 AK302906 BAG64076 AK315940 BAH14311 AY358711 AAQ89951 BC033091 AAH33091 BP310559 CB243903 DA144842 DC314392 DR002070 XM_005249483 XP_005249540 XM_005249485 XP_005249542 XR_427858 NM_001204051 NP_001190980 NM_001204052 NP_001190981 NM_004277 NP_004268
|
| Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.
|
| Subcellular Location |
Mitochondrion inner membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.
|
![Western Blot: UCP4 Overexpression Lysate (Adult Normal) [NBP2-10579] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UCP4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6806_UCP4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10579-img0001.jpg)