Gene Symbol | SLC25A27 |
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Entrez Gene | 9481 |
Alt Symbol | UCP4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 25, member 27 |
Other Description | UCP 4|mitochondrial uncoupling protein 4|uncoupling protein 4 |
Swissprots | Q8N518 O95847 Q5VTS9 F5GWR4 |
Accessions | EAX04298 EAX04299 O95847 AF110532 AAD16995 AK090871 AK291427 BAF84116 AK295233 BAG58226 AK302906 BAG64076 AK315940 BAH14311 AY358711 AAQ89951 BC033091 AAH33091 BP310559 CB243903 DA144842 DC314392 DR002070 XM_005249483 XP_005249540 XM_005249485 XP_005249542 XR_427858 NM_001204051 NP_001190980 NM_001204052 NP_001190981 NM_004277 NP_004268 |
Function | UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain. |
Subcellular Location | Mitochondrion inner membrane; Multi-pass membrane protein. |
Tissue Specificity | Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra. |
UCP4 CRISPR/Cas9 KO Plasmid (h) - sc-417530 from Santa Cruz Biotechnology
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UCP4 HDR Plasmid (h) - sc-417530-HDR from Santa Cruz Biotechnology
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UCP4 Double Nickase Plasmid (h) - sc-417530-NIC from Santa Cruz Biotechnology
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UCP4 Double Nickase Plasmid (h2) - sc-417530-NIC-2 from Santa Cruz Biotechnology
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UCP4 CRISPR Activation Plasmid (h) - sc-417530-ACT from Santa Cruz Biotechnology
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UCP4 CRISPR Activation Plasmid (h2) - sc-417530-ACT-2 from Santa Cruz Biotechnology
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UCP4 Lentiviral Activation Particles (h) - sc-417530-LAC from Santa Cruz Biotechnology
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UCP4 Lentiviral Activation Particles (h2) - sc-417530-LAC-2 from Santa Cruz Biotechnology
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UCP4 siRNA (h) - sc-36775 from Santa Cruz Biotechnology
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UCP4 shRNA Plasmid (h) - sc-36775-SH from Santa Cruz Biotechnology
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UCP4 shRNA (h) Lentiviral Particles - sc-36775-V from Santa Cruz Biotechnology
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UCP4 RNAi - H00009481-R01 from Novus Biologicals
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MISSION® esiRNA - EHU078151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19496 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19496 from Sigma-Aldrich
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SLC25A27 siRNA (Human) - CRH6296 from Cohesion Biosciences
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SLC25A27 - MBS8209677 from MyBioSource
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shRNA set against Human SLC25A27 (NM_004277.4) - SHH409608 from Creative biogene
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Human SLC25A27 siRNA - orb266798 from Biorbyt
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SLC25A27 shRNA Plasmid (Human) - CHH6296 from Cohesion Biosciences
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SLC25A27 miRNA 3'UTR clone - MiUTR3H-13012 from Creative biogene
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