Gene Symbol | PMCH |
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Entrez Gene | 5367 |
Alt Symbol | MCH |
Species | Human |
Gene Type | protein-coding |
Description | pro-melanin-concentrating hormone |
Other Description | pro-MCH |
Swissprots | Q16044 Q8WVG0 P20382 |
Accessions | AAB27493 EAW97693 P20382 AV723033 BC018048 AAH18048 CB047053 DQ892335 ABM83261 DQ895540 ABM86466 M57703 AAA63214 NM_002674 NP_002665 |
Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation. |
Subcellular Location | Secreted. |
Tissue Specificity | Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. {ECO:0000269|PubMed:9191099}. |
pro-MCH CRISPR/Cas9 KO Plasmid (h) - sc-417543 from Santa Cruz Biotechnology
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pro-MCH HDR Plasmid (h) - sc-417543-HDR from Santa Cruz Biotechnology
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pro-MCH Double Nickase Plasmid (h) - sc-417543-NIC from Santa Cruz Biotechnology
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pro-MCH Double Nickase Plasmid (h2) - sc-417543-NIC-2 from Santa Cruz Biotechnology
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pro-MCH CRISPR Activation Plasmid (h) - sc-417543-ACT from Santa Cruz Biotechnology
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pro-MCH CRISPR Activation Plasmid (h2) - sc-417543-ACT-2 from Santa Cruz Biotechnology
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pro-MCH Lentiviral Activation Particles (h) - sc-417543-LAC from Santa Cruz Biotechnology
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pro-MCH Lentiviral Activation Particles (h2) - sc-417543-LAC-2 from Santa Cruz Biotechnology
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pro-MCH siRNA (h) - sc-42015 from Santa Cruz Biotechnology
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pro-MCH shRNA Plasmid (h) - sc-42015-SH from Santa Cruz Biotechnology
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pro-MCH shRNA (h) Lentiviral Particles - sc-42015-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU104811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17021 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01744 from Sigma-Aldrich
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PMCH siRNA (Human) - CRH3604 from Cohesion Biosciences
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shRNA set against Human PMCH (NM_002674.2) - SHH378332 from Creative biogene
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shRNA set against Human PMCH(NM_002674.2) - SHR123618 from Creative biogene
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PMCH shRNA Plasmid (Human) - CHH3604 from Cohesion Biosciences
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PMCH miRNA 3'UTR clone - MiUTR1H-08023 from Creative biogene
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