Gene Symbol | TCAF1 |
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Entrez Gene | 9747 |
Alt Symbol | FAM115A |
Species | Human |
Gene Type | protein-coding |
Description | TRPM8 channel-associated factor 1 |
Other Description | TRP channel-associated factor 1|family with sequence similarity 115, member A|protein FAM115A |
Swissprots | Q9Y4C2 Q9BW63 Q7L665 Q75KM8 A8K6E0 Q75KM9 |
Accessions | AAQ96852 AAQ96853 EAW55623 Q9Y4C2 AB018281 BAA34458 AF086218 AF119896 AAF69650 AK001640 AK291605 BAF84294 AK294312 BAH11732 AK299911 BAG61749 BC000609 AAH00609 BC039457 BU947884 DA196926 DA317873 DQ786274 XM_005250074 XP_005250131 XM_005250075 XP_005250132 XM_005250076 XP_005250133 XM_005250077 XP_005250134 XM_006716191 XP_006716254 XM_006716192 XP_006716255 NM_001206938 NP_001193867 NM_001206941 NP_001193870 NM_014719 NP_055534 |
Function | Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner. {ECO:0000269|PubMed:25559186}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:25559186}. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269|PubMed:25559186}. |
Tissue Specificity | Isoform 2 is expressed in the prostate and strongly expressed in cancerous prostate samples. {ECO:0000269|PubMed:25559186}. |
FAM115A CRISPR/Cas9 KO Plasmid (h) - sc-409750 from Santa Cruz Biotechnology
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FAM115A HDR Plasmid (h) - sc-409750-HDR from Santa Cruz Biotechnology
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FAM115A Double Nickase Plasmid (h) - sc-409750-NIC from Santa Cruz Biotechnology
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FAM115A Double Nickase Plasmid (h2) - sc-409750-NIC-2 from Santa Cruz Biotechnology
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FAM115A CRISPR Activation Plasmid (h) - sc-409750-ACT from Santa Cruz Biotechnology
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FAM115A CRISPR Activation Plasmid (h2) - sc-409750-ACT-2 from Santa Cruz Biotechnology
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FAM115A Lentiviral Activation Particles (h) - sc-409750-LAC from Santa Cruz Biotechnology
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FAM115A Lentiviral Activation Particles (h2) - sc-409750-LAC-2 from Santa Cruz Biotechnology
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FAM115A siRNA (h) - sc-89631 from Santa Cruz Biotechnology
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FAM115A shRNA Plasmid (h) - sc-89631-SH from Santa Cruz Biotechnology
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FAM115A shRNA (h) Lentiviral Particles - sc-89631-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN8132 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8132 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08727 from Sigma-Aldrich
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FAM115A siRNA (Human) - CRH6514 from Cohesion Biosciences
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FAM115A - MBS8227169 from MyBioSource
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shRNA set against Human FAM115A (NM_014719.2) - SHH289185 from Creative biogene
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FAM115A shRNA Plasmid (Human) - CHH6514 from Cohesion Biosciences
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FAM115A miRNA 3'UTR clone - MiUTR3H-14804 from Creative biogene
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