RBBP6

Gene Symbol RBBP6
Entrez Gene 5930
Alt Symbol MY038, P2P-R, PACT, RBQ-1, SNAMA
Species Human
Gene Type protein-coding
Description retinoblastoma binding protein 6
Other Description E3 ubiquitin-protein ligase RBBP6|RB-binding Q-protein 1|p53-associated cellular protein of testis|proliferation potential-related protein|protein P2P-R|retinoblastoma-binding Q protein 1|retinoblastoma-binding protein 6
Swissprots Q6P4C2 Q7Z6E8 Q6DKH4 Q9H5M5 Q15290 Q7Z6E9 Q147T5 Q8N0V2 Q6YNC9 Q9H3I8 Q9NPX4 Q96PH3
Accessions CCQ43380 EAW55789 EAW55790 EAW55791 EAW55792 Q7Z6E9 AB112074 BAC77636 AB112075 BAC77637 AF063596 AAG43155 AF116625 AAF71048 AF352051 AAL05625 AK023612 AK026954 BAB15600 AK303040 BAG64162 AL359564 CAB94869 AY072922 AAL68925 BC015318 AAH15318 BC029352 AAH29352 BC029649 BC030964 BC051317 BC063524 AAH63524 BC073938 AAH73938 BC101139 AAI01140 BC101140 AAI01141 BC101141 AAI01142 BC101142 AAI01143 BC114353 AAI14354 BC114354 AAI14355 BC118667 AAI18668 BC139830 AAI39831 BC172357 AAI72357 BF727303 BI489954 BM314442 BX648661 CB529116 CD638608 HQ447789 ADQ32273 X85133 CAA59445 XM_005255461 XP_005255518 XM_005255462 XP_005255519 NM_006910 NP_008841 NM_018703 NP_061173 NM_032626 NP_116015
Function E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
Subcellular Location Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.
Tissue Specificity Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. {ECO:0000269|PubMed:15475430}.

P2P-R (M-19) - sc-6359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P2P-R (M-19): sc-6359. Western blot analysis of P2P-R expression in K-562 whole cell lysate.

P2P-R (M-300) - sc-25548 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
P2P-R (M-300): sc-25548. Western blot analysis of P2P-R expression in non-transfected 293T: sc-117752 (A), mouse P2P-R transfected 293T: sc-127279 (B) and K-562 (C) whole cell lysates.

P2P-R (M56) - sc-9962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
P2P-R (M56): sc-9962. Western blot analysis of P2P-R expression in NIH/3T3 whole cell lysate.

Anti-Retinoblastoma binding protein 6 antibody - ab168511 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Retinoblastoma binding protein 6 antibody (ab168511) at 1 µg/mlLane 1 : Retinoblastoma binding protein 6 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-Retinoblastoma binding protein 6 antibody - ab195602 from Abcam

Prices $370.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human fetal testis tissue labeling Retinoblastoma binding protein 6 with ab195602 at 1/100 dilution.

Anti-Retinoblastoma binding protein 6 antibody - ab55787 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing Y79 cells stained with ab55787 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab55787, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Retinoblastoma binding protein 6 antibody - ab84832 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-Retinoblastoma binding protein 6 antibody (ab84832) at 1/250 dilution + Jurkat cell lysate

Anti-RBBP6 Antibody (aa1600-1650, Biotin) - LS-C143221 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa1600-1650, DY650) - LS-C143222 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa1600-1650, DY488) - LS-C143223 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa1600-1650, HRP) - LS-C143224 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa1600-1650, DY550) - LS-C143225 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody - LS-C136861 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa395-444) - LS-C110754 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RBBP6 antibody LS-C110754 Western blot of NCI-H226 cell lysate.

Anti-RBBP6 Antibody (aa20-70, Biotin) - LS-C143491 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa20-70, DY488) - LS-C143493 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa20-70, DY650) - LS-C143492 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa20-70, HRP) - LS-C143494 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa20-70, DY550) - LS-C143495 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody - LS-C180088 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody - LS-C180095 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody - LS-C137247 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa1582-1692, Azide-free) - LS-C328488 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-RBBP6 Antibody - LS-C341032 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RBBP6 Antibody (aa13-62) - LS-C201435 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human ACHN Whole cell . RBBP6 antibody dilution 1.0 ug/ml.
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