RBBP6
| Gene Symbol | RBBP6 |
|---|---|
| Entrez Gene | 5930 |
| Alt Symbol | MY038, P2P-R, PACT, RBQ-1, SNAMA |
| Species | Human |
| Gene Type | protein-coding |
| Description | retinoblastoma binding protein 6 |
| Other Description | E3 ubiquitin-protein ligase RBBP6|RB-binding Q-protein 1|p53-associated cellular protein of testis|proliferation potential-related protein|protein P2P-R|retinoblastoma-binding Q protein 1|retinoblastoma-binding protein 6 |
| Swissprots | Q6P4C2 Q7Z6E8 Q6DKH4 Q9H5M5 Q15290 Q7Z6E9 Q147T5 Q8N0V2 Q6YNC9 Q9H3I8 Q9NPX4 Q96PH3 |
| Accessions | CCQ43380 EAW55789 EAW55790 EAW55791 EAW55792 Q7Z6E9 AB112074 BAC77636 AB112075 BAC77637 AF063596 AAG43155 AF116625 AAF71048 AF352051 AAL05625 AK023612 AK026954 BAB15600 AK303040 BAG64162 AL359564 CAB94869 AY072922 AAL68925 BC015318 AAH15318 BC029352 AAH29352 BC029649 BC030964 BC051317 BC063524 AAH63524 BC073938 AAH73938 BC101139 AAI01140 BC101140 AAI01141 BC101141 AAI01142 BC101142 AAI01143 BC114353 AAI14354 BC114354 AAI14355 BC118667 AAI18668 BC139830 AAI39831 BC172357 AAI72357 BF727303 BI489954 BM314442 BX648661 CB529116 CD638608 HQ447789 ADQ32273 X85133 CAA59445 XM_005255461 XP_005255518 XM_005255462 XP_005255519 NM_006910 NP_008841 NM_018703 NP_061173 NM_032626 NP_116015 |
| Function | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. |
| Subcellular Location | Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome. |
| Tissue Specificity | Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer. {ECO:0000269|PubMed:15475430}. |
P2P-R CRISPR/Cas9 KO Plasmid (h) - sc-404165 from Santa Cruz Biotechnology
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P2P-R HDR Plasmid (h) - sc-404165-HDR from Santa Cruz Biotechnology
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P2P-R Double Nickase Plasmid (h) - sc-404165-NIC from Santa Cruz Biotechnology
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P2P-R Double Nickase Plasmid (h2) - sc-404165-NIC-2 from Santa Cruz Biotechnology
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P2P-R CRISPR Activation Plasmid (h) - sc-404165-ACT from Santa Cruz Biotechnology
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P2P-R CRISPR Activation Plasmid (h2) - sc-404165-ACT-2 from Santa Cruz Biotechnology
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P2P-R Lentiviral Activation Particles (h) - sc-404165-LAC from Santa Cruz Biotechnology
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P2P-R Lentiviral Activation Particles (h2) - sc-404165-LAC-2 from Santa Cruz Biotechnology
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P2P-R siRNA (h) - sc-40900 from Santa Cruz Biotechnology
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P2P-R shRNA Plasmid (h) - sc-40900-SH from Santa Cruz Biotechnology
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P2P-R shRNA (h) Lentiviral Particles - sc-40900-V from Santa Cruz Biotechnology
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RBBP6 RNAi - H00005930-R01 from Novus Biologicals
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RBBP6 RNAi - H00005930-R03 from Novus Biologicals
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MISSION® esiRNA - EHU086781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18012 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18012 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04110 from Sigma-Aldrich
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RBBP6 siRNA (Human) - CRH4016 from Cohesion Biosciences
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RBBP6 RNAi - H00005930-R02 from Novus Biologicals
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RBBP6 - MBS827246 from MyBioSource
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shRNA set against Human RBBP6 (NM_018703.3) - SHH390360 from Creative biogene
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shRNA set against Human RBBP6(NM_006910.4) - SHR167672 from Creative biogene
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shRNA set against Human RBBP6(NM_018703.3) - SHR167862 from Creative biogene
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shRNA set against Human RBBP6(NM_032626.5) - SHR167898 from Creative biogene
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shRNA set against Human RBBP6(NM_006910.4) - SHR167916 from Creative biogene
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