| Gene Symbol |
TRIM28
|
| Entrez Gene |
10155
|
| Alt Symbol |
KAP1, PPP1R157, RNF96, TF1B, TIF1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 28
|
| Other Description |
E3 SUMO-protein ligase TRIM28|KAP-1|KRAB [Kruppel-associated box domain]-associated protein 1|KRAB-associated protein 1|KRAB-interacting protein 1|KRIP-1|RING finger protein 96|TIF1-beta|nuclear corepressor KAP-1|protein phosphatase 1, regulatory subunit 157|transcription intermediary factor 1-beta|transcriptional intermediary factor 1-beta|tripartite motif-containing 28|tripartite motif-containing protein 28
|
| Swissprots |
Q13263 Q96IM1 Q7Z632 Q93040 O00677
|
| Accessions |
EAW72605 EAW72606 EAW72607 Q13263 AK131063 AK225760 AK313478 BAG36262 AL360114 AL360188 AL360189 BC004978 AAH04978 BC007390 AAH07390 BC052986 AAH52986 U31657 AAA74954 U78773 AAB37341 U95040 AAB51517 X97548 CAA66150 NM_005762 NP_005753
|
| Function |
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity towar
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10330177, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9016654}.
|