Gene Symbol | SV2A |
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Entrez Gene | 9900 |
Alt Symbol | SV2 |
Species | Human |
Gene Type | protein-coding |
Description | synaptic vesicle glycoprotein 2A |
Other Description | - |
Swissprots | Q9BVZ9 O94841 Q8NBJ6 D3DUZ7 Q7Z3L6 Q5QNX8 Q7L0J3 |
Accessions | CAG34345 CAI12572 CAI12573 CCQ43465 EAW53596 EAW53597 EAW53598 Q7L0J3 AB018279 BAA34456 AK075480 BAC11645 AK291718 BAF84407 AK303161 BAG64262 AM393578 CAL38455 BC000776 AAH00776 BC034038 BC045111 AAH45111 BP214143 BX537754 CAD97824 DA334809 DC305069 EU831489 ACE87176 EU831576 ACE86495 NM_001278719 NP_001265648 NM_014849 NP_055664 |
Function | Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}. |
Subcellular Location | Cell junction, synapse {ECO:0000250|UniProtKB:Q9JIS5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q02563}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02563}. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic- like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q02563, ECO:0000250|UniProtKB:Q9JIS5}. |
Top Pathways | ECM-receptor interaction |
SV2A CRISPR/Cas9 KO Plasmid (h) - sc-402098 from Santa Cruz Biotechnology
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SV2A HDR Plasmid (h) - sc-402098-HDR from Santa Cruz Biotechnology
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SV2A Double Nickase Plasmid (h) - sc-402098-NIC from Santa Cruz Biotechnology
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SV2A Double Nickase Plasmid (h2) - sc-402098-NIC-2 from Santa Cruz Biotechnology
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SV2A CRISPR Activation Plasmid (h) - sc-402098-ACT from Santa Cruz Biotechnology
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SV2A CRISPR Activation Plasmid (h2) - sc-402098-ACT-2 from Santa Cruz Biotechnology
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SV2A Lentiviral Activation Particles (h) - sc-402098-LAC from Santa Cruz Biotechnology
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SV2A Lentiviral Activation Particles (h2) - sc-402098-LAC-2 from Santa Cruz Biotechnology
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SV2A siRNA (h) - sc-36575 from Santa Cruz Biotechnology
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SV2A shRNA Plasmid (h) - sc-36575-SH from Santa Cruz Biotechnology
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SV2A shRNA (h) Lentiviral Particles - sc-36575-V from Santa Cruz Biotechnology
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SV2A RNAi - H00009900-R01 from Novus Biologicals
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MISSION® esiRNA - EHU076871 from Sigma-Aldrich
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MISSION® esiRNA - EHU022581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20862 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20862 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09331 from Sigma-Aldrich
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SV2A siRNA (Human) - CRH6645 from Cohesion Biosciences
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SV2A - MBS8211724 from MyBioSource
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shRNA set against Human SV2A(NM_014849.3) - SHL049060 from Creative biogene
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SV2A shRNA Plasmid (Human) - CHH6645 from Cohesion Biosciences
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SV2A miRNA 3'UTR clone - MiUTR1H-10091 from Creative biogene
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