| Gene Symbol |
BACH2
|
| Entrez Gene |
60468
|
| Alt Symbol |
BTBD25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BTB and CNC homology 1, basic leucine zipper transcription factor 2
|
| Other Description |
BTB and CNC homolog 2|transcription regulator protein BACH2
|
| Swissprots |
Q5T793 E1P518 Q9NTS5 Q59H70 Q9BYV9
|
| Accessions |
CBX47436 EAW48530 EAW48531 EAW48532 EAW48533 EAW48534 Q9BYV9 AA885077 AB208889 BAD92126 AF357835 AAK48898 AI524722 AJ271878 CAC28130 AK309526 AL512739 BC070239 BC166613 AAI66613 CN261405 DB077323 DB240991 HE578163 CCD17752 HE578164 CCD17753 HE578165 CCD17754 HE578166 CCD17755 HE578167 CCD17756 HE578168 CCD17757 HE578169 CCD17758 HE578170 CCD17759 HE578171 CCD17760 HE578172 CCD17761 HE578173 CCD17762 HE578174 CCD17763 HE578175 CCD17764 HE578176 CCD17765 XM_005248758 XP_005248815 XM_005248759 XP_005248816 XM_011536037 XP_011534339 XM_011536038 XP_011534340 XM_011536039 XP_011534341 XM_011536040 XP_011534342 XM_011536041 XP_011534343 XM_011536042 XP_011534344 XM_011536043 XP_011534345 NM_001170794 NP_001164265 NM_021813 NP_068585
|
| Function |
Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. {ECO:0000250, ECO:0000269|PubMed:17018862}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17018862}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:17018862}. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation.
|
| Tissue Specificity |
B-cell specific.
|
![Western Blot: BACH2 Overexpression Lysate (Adult Normal) [NBL1-07899] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for BACH2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/9166_BACH2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07899-img0002.jpg)