| Gene Symbol |
MCM4
|
| Entrez Gene |
4173
|
| Alt Symbol |
CDC21, CDC54, NKCD, NKGCD, P1-CDC21, hCdc21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
minichromosome maintenance complex component 4
|
| Other Description |
CDC21 homolog|DNA replication licensing factor MCM4|homolog of S. pombe cell devision cycle 21|minichromosome maintenance deficient 4
|
| Swissprots |
Q8NEH1 P33991 Q99658
|
| Accessions |
AAB51723 AAC52018 AAS83108 CBX85473 EAW86684 EAW86685 EAW86686 P33991 AK022899 BAG51132 AK296913 BAG59468 AK309812 AM493756 CAM35476 BC031061 AAH31061 BF793151 BM781972 BQ058022 BQ689703 X74794 CAA52801 XM_005251234 XP_005251291 NM_005914 NP_005905 NM_182746 NP_877423
|
| Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269|PubMed:9305914}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
DNA replication, Cell cycle
|
![Western Blot: MCM4 Overexpression Lysate (Adult Normal) [NBL1-12953] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCM4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6115_MCM4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12953-img0002.jpg)