| Gene Symbol | HMGN3 |
|---|---|
| Entrez Gene | 9324 |
| Alt Symbol | PNAS-24, PNAS-25, TRIP7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | high mobility group nucleosomal binding domain 3 |
| Other Description | TR-interacting protein 7|high mobility group nucleosome-binding domain-containing protein 3|thyroid hormone receptor interacting protein 7 |
| Swissprots | Q7RTT0 Q5HYD3 Q9BZT7 B2RD37 Q969M5 Q15651 |
| Accessions | EAW48711 EAW48712 EAW48713 EAW48714 EAW48715 Q15651 AF274949 AAK07526 AF401520 AAK92012 AK124181 AK315391 BAG37784 AY043282 AAK85736 BC009529 AAH09529 BF790582 BI551210 BK000003 DAA00392 BK000006 DAA00395 BX648085 CAI46267 L40357 AAA73877 XM_005248768 XP_005248825 XM_005248769 XP_005248826 XM_006715604 XP_006715667 NM_001201362 NP_001188291 NM_001201363 NP_001188292 NM_004242 NP_004233 NM_138730 NP_620058 |
| Function | Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries. {ECO:0000269|PubMed:11356838, ECO:0000269|PubMed:7776974}. |