| Gene Symbol |
SULF1
|
| Entrez Gene |
23213
|
| Alt Symbol |
HSULF-1, SULF-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sulfatase 1
|
| Other Description |
extracellular sulfatase Sulf-1|sulfatase FP
|
| Swissprots |
Q9UPS5 Q86YV8 Q8IWU6 Q8NCA2
|
| Accessions |
EAW86953 EAW86954 EAW86955 Q8IWU6 AB029000 BAA83029 AF545571 AAO33315 AK055467 AK055607 AK074873 BAC11258 AK095341 AK123744 AK307951 AL136772 CAB66706 AY101175 AAM76860 BC012997 AAH12997 BC068565 AAH68565 BX571746 CAE11871 DA234578 DA726387 DA745191 EU831658 ACE87258 EU831741 ACE86575 XM_006716438 XP_006716501 XM_006716439 XP_006716502 XM_006716440 XP_006716503 XM_006716441 XP_006716504 XM_006716442 XP_006716505 XM_011517494 XP_011515796 XM_011517495 XP_011515797 XR_928764 NM_001128204 NP_001121676 NM_001128205 NP_001121677 NM_001128206 NP_001121678 NM_015170 NP_055985
|
| Function |
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}.
|
| Tissue Specificity |
Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.
|
![Western Blot: Sulfatase 1 Overexpression Lysate (Adult Normal) [NBP2-10298] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Sulfatase 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2115_Sulfatase%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10298-img0001.jpg)