BTK

Gene Symbol	BTK
Entrez Gene	695
Alt Symbol	AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
Species	Human
Gene Type	protein-coding
Description	Bruton agammaglobulinemia tyrosine kinase
Other Description	B-cell progenitor kinase|agammaglobulinaemia tyrosine kinase|dominant-negative kinase-deficient Brutons tyrosine kinase|truncated Bruton agammaglobulinemia tyrosine kinase|tyrosine-protein kinase BTK|tyrosine-protein kinase BTK isoform (lacking exon 14)
Swissprots	B2RAW1 Q32ML5 Q06187
Accessions	AAA61479 AAB60639 AAB64205 AAC51347 AAZ38824 EAX02856 EAX02857 EAX02858 Q06187 AF153364 AAF61477 AF153755 AAF37332 AF153756 AAF37333 AF153757 AAF37334 AF153758 AAF37335 AF153759 AAF37336 AF153760 AAF37337 AF153761 AAF37338 AF153762 AAF37339 AF153763 AAF37340 AF153764 AAF37341 AJ888376 CAI59842 AJ888377 CAI59836 AJ888378 CAI59837 AJ888379 CAI59838 AJ888380 CAI59839 AJ888381 CAI59840 AK057105 BAG51864 AK225577 AK309851 AK314382 BAG37008 AM051275 CAJ19681 AM051276 CAJ19682 AM051277 CAJ19683 AM051278 CAJ19684 AM051279 CAJ19685 AM051280 CAJ19686 AM051281 CAJ19687 AM051282 CAJ19688 AM051283 CAJ19689 AM051284 CAJ19690 AM051285 CAJ19691 AM051286 CAJ19692 AU107296 AV733045 BC109079 AAI09080 BC109080 AAI09081 DA619542 DB331677 DB636737 KF241986 AGW32074 X58957 CAA41728 NM_000061 NP_000052 NM_001287344 NP_001274273 NM_001287345 NP_001274274
Function	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. E
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
Tissue Specificity	Predominantly expressed in B-lymphocytes.
Top Pathways	B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency, Osteoclast differentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BTK ELISA Kit (Sandwich ELISA) - LS-F5728 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse/Human/Rat Phospho-BTK (Tyr223) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1072 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.156-10 ng/ml

Mouse/Human/Rat BTK ELISA Kit (Cell-Based ELISA) - LS-F1835 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Rat BTK ELISA Kit (Sandwich ELISA) - LS-F9744 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.06 ng/ml Range 0.156-10 ng/ml

Human BTK ELISA Kit (Sandwich ELISA) - LS-F10964 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Mouse BTK ELISA Kit (Sandwich ELISA) - LS-F10965 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Phosphotyrosine BTK / Tyrosine-protein Kinase BTK ELISA Kit - RAB0938 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human Btk ELISA Kit - abx150845 from Abbexa Category ELISA Kit Sensitivity 0.054 ng/ml Range 0.156 ng/ml - 10 ng/ml

Anti-Thrombin, AT, Human, ELISA Kit - E-EL-H0432 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000ng/mL

Bruton'S Tyrosine Kinase (Btk), Human, ELISA Kit - SEB915Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.059ng/mL Range 0.156-10ng/mL

Tyrosine-protein kinase BTK (BTK), Human, ELISA Kit - E01T0603 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Tyrosine-protein kinase BTK, BTK, Human, ELISA Kit - E1915h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Anti-Trypsin, AT, Mouse, ELISA Kit - E-EL-M0126 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Anti-Thrombin, AT, Rabbit, ELISA Kit - E-EL-RB0952 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Anti-Thrombin, AT, Chicken, ELISA Kit - E-EL-Ch1596 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Anti-Thrombin, AT, Porcine, ELISA Kit - E-EL-P1079 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Anti-Thrombin, AT, Monkey, ELISA Kit - E-EL-MK0090 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human Phospho-BTK (Y551) ELISA - PEL-BTK-Y551 from RayBiotech Category ELISA Kit Prices $481.00, $866.00, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human Btk ELISA Kit - HB0703 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human AT ELISA Kit - HA0893 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine AT ELISA Kit - AA0893 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PI3K2a ELISA Kit - AP0100 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

BTK Colorimetric Cell-Based ELISA Kit - CB5081 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

BTK (Phospho-Tyr223) Colorimetric Cell-Based ELISA Kit - CBP1047 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human AT(Anti Thrombin) ELISA Kit - E-EL-H0432 from Elabscience Category ELISA Kit Sensitivity 18.75 ng/mL Range 31.25—2000 ng/mL

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