CNOT1

Gene Symbol	CNOT1
Entrez Gene	23019
Alt Symbol	AD-005, CDC39, NOT1, NOT1H
Species	Human
Gene Type	protein-coding
Description	CCR4-NOT transcription complex, subunit 1
Other Description	CCR4-NOT transcription complex subunit 1|CCR4-associated factor 1|NOT1 (negative regulator of transcription 1, yeast) homolog|adrenal gland protein AD-005|negative regulator of transcription subunit 1 homolog
Swissprots	Q8IWB8 Q9UFR8 Q9BVZ6 Q9Y2L0 Q9UI27 Q8TB53 Q7Z3K2 Q68DX7 A5YKK6
Accessions	A5YKK6 AB023224 BAA76851 AF110778 AAF14861 AJ346264 AK056927 BAG51828 AK075125 AK092885 BAG52622 AK300281 BAG62040 AK301092 BAH13408 AK302495 BAG63779 AL117492 CAB55960 AL832769 AL833549 BC000779 AAH00779 BC011861 BC024317 AAH24317 BC027969 BC040523 AAH40523 BM023419 BM968443 BX537840 CAD97851 BX647815 CB162525 CR749237 CAH18093 DB456343 DQ579255 EF553522 ABQ66268 NM_001265612 NP_001252541 NM_016284 NP_057368 NM_206999 NP_996882 NR_049763
Function	Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269|PubM
Subcellular Location	Cytoplasm, P-body {ECO:0000269|PubMed:21976065}. Nucleus {ECO:0000305|PubMed:21976065}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
Tissue Specificity	Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. {ECO:0000269|PubMed:10637334}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CNOT1 (Y-15) - sc-242483 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CNOT1 (N-18) - sc-242481 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-NOT1 / CNOT1 Antibody - LS-C335614 from LifeSpan Bioscience Prices $305.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CNOT1 Antibody - NBP2-32045 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CNOT1 Antibody - NBP2-31892 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CNOT1 Antibody - H00023019-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-CNOT1 antibody produced in rabbit - HPA046577 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CNOT1 antibody produced in rabbit - HPA049664 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti -CNOT1 (CCR4-NOT Transcription Complex Subunit 1, NOT1, CDC39, NOT1H, AD-005) - 210187 from USBiological Life Science Host Rabbit Clonality Polyclonal

CNOT1 Polyclonal Antibody - A5969 from ABclonal Prices $130.00, $220.00, $380.00 Sizes 50 µl, 100 µl, 200 µl Host Rabbit Clonality Polyclonal

CNOT1 antibody - 70R-16478 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

CNOT1 Antibody - abx004580 from Abbexa Host Rabbit Clonality Polyclonal

CNOT1 antibody - 14276-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

CNOT1 antibody - H00023019-A01 from Acris Antibodies Prices $300.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-CNOT1, Polyclonal Antibody - 25-A5969 from ARP American Research Products Prices $279.00, $549.00 Sizes 50 µg, 200 µg Host Rabbit Clonality Polyclonal

CNOT1 antibody - 14276-1-AP from Proteintech Group Prices $279.00 Sizes con: 41 μg/150μl Host Rabbit Clonality Polyclonal

CNOT1 antibody - STJ27765 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal

CNOT1 - A5969 from NeoScientific Prices $480.00 Sizes 200 µg Host Rabbit Clonality Polyclonal

CCR4-NOT transcription complex, subunit 1 , Polyclonal Antibody - MBS711096 from MyBioSource Prices $230.00, $500.00 Sizes 50 µl, 150 µl Host Rabbit Clonality Polyclonal

CNOT1, Polyclonal Antibody - MBS2521164 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

CNOT1 , Polyclonal Antibody - MBS129782 from MyBioSource Prices $230.00, $305.00, $460.00 Sizes 50 µl, 100 µl, 200 µl Clonality Polyclonal

CNOT1 Antibody - EPP11695 from Elabscience Prices $296.00, $485.00 Sizes 120 μl, 200 μl Host Rabbit Clonality Polyclonal

Anti-CNOT1 (aa 2278-2375) polyclonal antibody - DPAB-DC1031 from Creative Diagnostics Host Mouse Clonality Polyclonal

CNOT1 (H-300) - sc-383116 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CNOT1 Antibody,Biotin conjugated - CSB-PA005663LD01HU from Cusabio Host Rabbit Clonality Polyclonal

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