| Gene Symbol | CH25H |
|---|---|
| Entrez Gene | 9023 |
| Alt Symbol | C25H |
| Species | Human |
| Gene Type | protein-coding |
| Description | cholesterol 25-hydroxylase |
| Other Description | cholesterol 25-monooxygenase|h25OH |
| Swissprots | B2RBY3 O95992 |
| Accessions | AAC97481 CAR81282 CBX84760 EAW50146 O95992 AF059214 AAC97483 AK314865 BAG37380 BC017843 AAH17843 BC072430 AAH72430 DQ892026 ABM82952 DQ895218 ABM86144 NM_003956 NP_003947 |
| Function | Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000269|PubMed:9852097}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Top Pathways | Primary bile acid biosynthesis |