| Gene Symbol |
CH25H
|
| Entrez Gene |
9023
|
| Alt Symbol |
C25H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cholesterol 25-hydroxylase
|
| Other Description |
cholesterol 25-monooxygenase|h25OH
|
| Swissprots |
B2RBY3 O95992
|
| Accessions |
AAC97481 CAR81282 CBX84760 EAW50146 O95992 AF059214 AAC97483 AK314865 BAG37380 BC017843 AAH17843 BC072430 AAH72430 DQ892026 ABM82952 DQ895218 ABM86144 NM_003956 NP_003947
|
| Function |
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000269|PubMed:9852097}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
Primary bile acid biosynthesis
|