| Gene Symbol | SORBS1 |
|---|---|
| Entrez Gene | 10580 |
| Alt Symbol | CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | sorbin and SH3 domain containing 1 |
| Other Description | Fas-ligand associated factor 2|SH3 domain protein 5|c-Cbl associated protein|ponsin|sorbin and SH3 domain-containing protein 1 |
| Swissprots | Q5T927 Q96KF3 Q5T928 Q9P2Q0 Q5T931 A6NID8 Q9BX64 Q8IVK0 Q96KF4 Q9UHN7 Q5T924 Q5T923 Q5T930 Q9Y338 Q9BX66 D3DR42 Q9BX65 A6NEK3 Q9UFT2 A6NJS4 A7MD40 O43857 A0AED4 Q5T929 Q5T932 Q7LBE5 Q8IVQ4 |
| Accessions | EAW49998 EAW49999 EAW50000 EAW50001 EAW50002 EAW50003 EAW50004 EAW50005 EAW50006 EAW50007 EAW50008 Q9BX66 AB037717 BAA92534 AF136380 AAD27647 AF136381 AAF22175 AF330623 AAK57479 AF330624 AAK57480 AF356525 AAK37563 AF356526 AAK37564 AF356527 AAK37565 AJ489942 CAD34588 AK022468 AK294924 BAG58006 AK300407 BAG62137 AK304130 BAG65026 AK304753 BAH14253 AL117472 CAB55947 AL122082 AL707894 AL832353 AM260536 CAJ97431 AM393082 CAL37960 BC042612 AAH42612 BC152463 AAI52464 BC160134 AAI60134 BX640814 CAE45892 DC334283 U70668 AAB93496 XM_006717570 XP_006717633 XM_006717574 XP_006717637 XM_006717581 XP_006717644 XM_006717582 XP_006717645 XM_006717585 XP_006717648 XM_006717586 XP_006717649 XM_006717589 XP_006717652 XM_006717590 XP_006717653 XM_006717591 XP_006717654 XM_006717593 XP_006717656 XM_006717594 XP_006717657 XM_006717595 XP_006717658 XM_011539136 XP_011537438 XM_011539137 XP_011537439 XM_011539138 XP_011537440 XM_011539139 XP_011537441 XM_011539140 XP_011537442 XM_011539141 XP_011537443 XM_011539142 XP_011537444 XM_011539143 XP_011537445 XM_011539144 XP_011537446 XM_011539145 XP_011537447 XM_011539146 XP_011537448 XM_011539147 XP_011537449 XM_011539148 XP_011537450 XM_011539149 XP_011537451 XM_011539150 XP_011537452 XM_011539151 XP_011537453 XM_011539152 XP_011537454 XM_011539153 XP_011537455 XM_011539154 XP_011537456 XM_011539155 XP_011537457 XM_011539156 XP_011537458 XM_011539157 XP_011537459 XM_011539158 XP_011537460 XM_011539159 XP_011537461 XM_011539160 XP_011537462 XM_011539161 XP_011537463 XM_011539162 XP_011537464 XM_011539163 XP_011537465 XM_011539164 XP_011537466 XM_011539165 XP_011537467 XM_011539166 XP_011537468 XM_011539167 XP_011537469 XM_011539168 XP_011537470 XM_011539169 XP_011537471 NM_001034954 NP_001030126 NM_001034955 NP_001030127 NM_001034956 NP_001030128 NM_001034957 NP_001030129 NM_001290294 NP_001277223 NM_001290295 NP_001277224 NM_001290296 NP_001277225 NM_001290297 NP_001277226 NM_001290298 NP_001277227 NM_006434 NP_006425 NM_015385 NP_056200 NM_024991 NP_079267 |
| Function | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity). {ECO:0000250|UniProtKB:Q62417}. |
| Subcellular Location | Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}. |
| Tissue Specificity | Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:11374898, ECO:0000269|PubMed:17462669}. |
| Top Pathways | Adherens junction, Insulin signaling pathway, PPAR signaling pathway |
CAP CRISPR/Cas9 KO Plasmid (h) - sc-404737 from Santa Cruz Biotechnology
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CAP HDR Plasmid (h) - sc-404737-HDR from Santa Cruz Biotechnology
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CAP Double Nickase Plasmid (h) - sc-404737-NIC from Santa Cruz Biotechnology
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CAP Double Nickase Plasmid (h2) - sc-404737-NIC-2 from Santa Cruz Biotechnology
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CAP CRISPR Activation Plasmid (h) - sc-404737-ACT from Santa Cruz Biotechnology
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CAP CRISPR Activation Plasmid (h2) - sc-404737-ACT-2 from Santa Cruz Biotechnology
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CAP Lentiviral Activation Particles (h) - sc-404737-LAC from Santa Cruz Biotechnology
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CAP Lentiviral Activation Particles (h2) - sc-404737-LAC-2 from Santa Cruz Biotechnology
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CAP siRNA (h) - sc-40339 from Santa Cruz Biotechnology
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CAP shRNA Plasmid (h) - sc-40339-SH from Santa Cruz Biotechnology
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CAP shRNA (h) Lentiviral Particles - sc-40339-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU096031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20333 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20333 from Sigma-Aldrich
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SORBS1 siRNA (Human) - CRH7200 from Cohesion Biosciences
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SORBS1 - MBS8235463 from MyBioSource
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shRNA set against Human Sorbs1 (NM_006434.2) - SHH415104 from Creative biogene
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shRNA set against Human SORBS1(NM_001034955.1) - SHL016356 from Creative biogene
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shRNA set against Human SORBS1(NM_024991.1) - SHL016374 from Creative biogene
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shRNA set against Human SORBS1(NM_001034956.1) - SHL016392 from Creative biogene
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shRNA set against Human SORBS1(NM_006434.2) - SHL016444 from Creative biogene
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shRNA set against Human SORBS1(NM_001034954.1) - SHL024780 from Creative biogene
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shRNA set against Human SORBS1(NM_001034957.1) - SHL024816 from Creative biogene
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shRNA set against Human SORBS1(NM_015385.2) - SHL024870 from Creative biogene
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SORBS1 shRNA Plasmid (Human) - CHH7200 from Cohesion Biosciences
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