Gene Symbol | BCKDHA |
---|---|
Entrez Gene | 593 |
Alt Symbol | BCKDE1A, MSU, MSUD1, OVD1A |
Species | Human |
Gene Type | protein-coding |
Description | branched chain keto acid dehydrogenase E1, alpha polypeptide |
Other Description | 2-oxoisovalerate dehydrogenase (lipoamide)|2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial|BCKDH E1-alpha|branched-chain alpha-keto acid dehydrogenase E1 component alpha chain |
Swissprots | P12694 Q16472 B4DP47 Q16034 E7EW46 |
Accessions | AAB19267 EAW57039 EAW57040 P12694 AB209828 BAD93065 AK298188 BAG60459 AK313300 BAG36106 AL833143 CAH56215 BC007878 AAH07878 BC008933 AAH08933 BC023983 AAH23983 BE223026 BG742673 BI910860 BM702667 BQ018849 J04474 AAB59549 M22221 AAA35590 Z14093 CAA78475 NM_000709 NP_000700 NM_001164783 NP_001158255 |
Function | The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). |
Subcellular Location | Mitochondrion matrix. |
Top Pathways | Valine, leucine and isoleucine degradation |
BCKDE1A CRISPR/Cas9 KO Plasmid (h) - sc-417950 from Santa Cruz Biotechnology
|
||||||||
BCKDE1A HDR Plasmid (h) - sc-417950-HDR from Santa Cruz Biotechnology
|
||||||||
BCKDE1A Double Nickase Plasmid (h) - sc-417950-NIC from Santa Cruz Biotechnology
|
||||||||
BCKDE1A Double Nickase Plasmid (h2) - sc-417950-NIC-2 from Santa Cruz Biotechnology
|
||||||||
BCKDE1A CRISPR Activation Plasmid (h) - sc-417950-ACT from Santa Cruz Biotechnology
|
||||||||
BCKDE1A CRISPR Activation Plasmid (h2) - sc-417950-ACT-2 from Santa Cruz Biotechnology
|
||||||||
BCKDE1A Lentiviral Activation Particles (h) - sc-417950-LAC from Santa Cruz Biotechnology
|
||||||||
BCKDE1A Lentiviral Activation Particles (h2) - sc-417950-LAC-2 from Santa Cruz Biotechnology
|
||||||||
BCKDE1A siRNA (h) - sc-105117 from Santa Cruz Biotechnology
|
||||||||
BCKDE1A shRNA Plasmid (h) - sc-105117-SH from Santa Cruz Biotechnology
|
||||||||
BCKDE1A shRNA (h) Lentiviral Particles - sc-105117-V from Santa Cruz Biotechnology
|
||||||||
BCKDHA RNAi - H00000593-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU003271 from Sigma-Aldrich
|
||||||||
MISSION® esiRNA - EHU230591 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3901 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3901 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR02970 from Sigma-Aldrich
|
||||||||
BCKDHA siRNA (Human) - CRH0406 from Cohesion Biosciences
|
||||||||
BCKDHA - MBS8210381 from MyBioSource
|
||||||||
shRNA set against Human BCKDHA (NM_000709.3) - SHH245810 from Creative biogene
|
||||||||
Human BCKDHA siRNA - orb260908 from Biorbyt
|
||||||||
BCKDHA shRNA Plasmid (Human) - CHH0406 from Cohesion Biosciences
|
||||||||
BCKDHA miRNA 3'UTR clone - MiUTR3H-09933 from Creative biogene
|
||||||||
BCKDHA miRNA 3'UTR clone - MiUTR3H-09934 from Creative biogene
|