Gene Symbol | GNA11 |
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Entrez Gene | 2767 |
Alt Symbol | FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2 |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) |
Other Description | G-protein subunit alpha-11|g alpha-11|guanine nucleotide-binding protein G(y) subunit alpha|guanine nucleotide-binding protein subunit alpha-11 |
Swissprots | P29992 O15109 Q14350 Q6IB00 |
Accessions | AAC25615 EAW69339 EAW69340 P29992 AB209435 BAD92672 AF011497 AAB64303 AF493900 AAM12614 AK091639 AL110227 CAH56407 BC001528 BC051315 BC063426 BC089041 AAH89041 BC096225 AAH96225 BC096226 AAH96226 BC096227 AAH96227 BC111027 CR457004 CAG33285 HY118575 L40630 AAA99949 M69013 AAA58624 NM_002067 NP_002058 |
Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. |
Subcellular Location | Cell membrane {ECO:0000305|PubMed:18703424}; Lipid-anchor {ECO:0000305|PubMed:18703424}. Cytoplasm {ECO:0000269|PubMed:18703424}. Note=In testicular cells, expressed exclusively in the cytoplasm. |
Tissue Specificity | Expressed in testis. {ECO:0000269|PubMed:18703424}. |
Top Pathways | Gap junction, Vascular smooth muscle contraction, Chagas disease (American trypanosomiasis), Amoebiasis, Calcium signaling pathway |
G α 11 CRISPR/Cas9 KO Plasmid (h) - sc-401653 from Santa Cruz Biotechnology
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G α 11 HDR Plasmid (h) - sc-401653-HDR from Santa Cruz Biotechnology
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G α 11 Double Nickase Plasmid (h) - sc-401653-NIC from Santa Cruz Biotechnology
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G α 11 Double Nickase Plasmid (h2) - sc-401653-NIC-2 from Santa Cruz Biotechnology
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G α 11 CRISPR Activation Plasmid (h) - sc-401653-ACT from Santa Cruz Biotechnology
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G α 11 CRISPR Activation Plasmid (h2) - sc-401653-ACT-2 from Santa Cruz Biotechnology
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G α 11 Lentiviral Activation Particles (h) - sc-401653-LAC from Santa Cruz Biotechnology
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G α 11 Lentiviral Activation Particles (h2) - sc-401653-LAC-2 from Santa Cruz Biotechnology
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G α 11 siRNA (h) - sc-41740 from Santa Cruz Biotechnology
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G α 11 shRNA Plasmid (h) - sc-41740-SH from Santa Cruz Biotechnology
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G α 11 shRNA (h) Lentiviral Particles - sc-41740-V from Santa Cruz Biotechnology
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GNA11 RNAi - H00002767-R01 from Novus Biologicals
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MISSION® esiRNA - EHU034691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9399 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9399 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01790 from Sigma-Aldrich
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GNA11 siRNA (Human) - CRH1838 from Cohesion Biosciences
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GNA11 - MBS8229656 from MyBioSource
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shRNA set against Human GNA11 (NM_002067.2) - SHH304558 from Creative biogene
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shRNA set against Human GNA11(NM_002067.2) - SHH090911 from Creative biogene
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Gα 11 CRISPR/Cas9 KO Plasmid (h2) - sc-401653-KO-2 from Santa Cruz Biotechnology
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Gα 11 HDR Plasmid (h2) - sc-401653-HDR-2 from Santa Cruz Biotechnology
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Human GNA11 siRNA - orb262340 from Biorbyt
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GNA11 shRNA Plasmid (Human) - CHH1838 from Cohesion Biosciences
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GNA11 miRNA 3'UTR clone - MiUTR1H-04097 from Creative biogene
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