| Gene Symbol |
ddb2
|
| Entrez Gene |
100004133
|
| Alt Symbol |
si:dkey-45f10.3
|
| Species |
Zebrafish
|
| Gene Type |
protein-coding
|
| Description |
damage-specific DNA binding protein 2
|
| Other Description |
DNA damage-binding protein 2|damage-specific DNA-binding protein 2
|
| Swissprots |
Q2YDS1 Q1LUF7 Q1LUF8
|
| Accessions |
Q2YDS1 BC110096 AAI10097 XM_005159034 XP_005159091 XM_005159035 XP_005159092 NM_001083061 NP_001076530
|
| Function |
Required for DNA repair. Binds to ddb1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Nucleotide excision repair, p53 signaling pathway, Ubiquitin mediated proteolysis
|