GABRB2

Gene Symbol GABRB2
Entrez Gene 2561
Alt Symbol -
Species Human
Gene Type protein-coding
Description gamma-aminobutyric acid (GABA) A receptor, beta 2
Other Description GABA(A) receptor subunit beta-2|GABA(A) receptor, beta 2|gamma-aminobutyric acid A receptor beta 2|gamma-aminobutyric acid receptor subunit beta-2
Swissprots Q16323 D1LYT1 Q4FZB2 P47870 D1LYT0 A8K115 A8K1A0
Accessions ACY71653 ACY71654 ACY71655 ACY71656 ACY71657 ACY71658 ACY71659 ACY71660 ACY71661 ACY71662 ACY71663 ACY71664 ACY71665 ACY71666 ACY71667 ACY71668 ACY71669 ACY71670 ACY71671 ACY71672 ACY71673 ACY71674 ACY71675 ACY71676 ACY71677 ACY71678 ACY71679 ACY71680 ACY71681 ACY71682 ACY71683 ACY71684 ACY71685 ACY71686 ACY71687 ACY71688 ACY71689 ACY71690 ACY71691 ACY71692 ACY71693 ACY71694 ACY71695 ACY71696 ACY71697 ACY71698 ACY71699 ACY71700 ACY71701 ACY71702 ACY71703 ACY71704 ACY71705 ACY71706 ACY71707 ACY71708 ACY71709 ACY71710 ACY71711 ACY71712 ACY71713 ACY71714 ACY71715 ACY71716 ACY71717 ACY71718 ACY71719 ACY71720 ACY71721 ACY71722 ACY71723 ACY71724 ACY71725 ACY71726 ACY71727 ACY71728 ACY71729 ACY71730 ACY71731 ACY71732 ACY71733 ACY71734 ACY71735 ACY71736 ACY71737 ACY71738 ACY71739 ACY71740 ACY71741 ACY71742 EAW61543 EAW61544 P47870 A28108 CAA01922 AK055125 AK289730 BAF82419 AK289815 BAF82504 AK294437 BAH11765 AK297609 BAH12626 BC036592 BC099705 AAH99705 BC099719 AAH99719 BC105639 AAI05640 GU086163 ACY69094 GU086164 ACY69095 S67368 AAB29370 S77553 AAB33982 S77554 AAB33983 XM_011534501 XP_011532803 NM_000813 NP_000804 NM_021911 NP_068711
Function Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:19763268, ECO:0000269|PubMed:8264558}.
Subcellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. {ECO:0000269|PubMed:16983389, ECO:0000269|PubMed:19763268}.
Top Pathways GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction

GABA A Rβ2 (C-20) - sc-7362 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>A</sub> Rβ2 (C-20): sc-7362. Western blot analysis of GABA<sub>A</sub> Rβ2 expression in mouse brain tissue extract.

GABA A Rβ2 (E-20) - sc-31429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GABA A Rβ2 (N-19) - sc-7363 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GABA A Rβ2 (R-18) - sc-31427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GABA<sub>A</sub> Rβ2 (R-18): sc-31427. Western blot analysis of GABA<sub>A</sub> Rβ2 expression in mouse brain tissue extract.

GABA A Rβ2 (S-19) - sc-31428 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GABA A Rβ2 (J-21) - sc-133601 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-GABA A Receptor beta 2 + 3 antibody [0.T.52] - ab34005 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 0.T.52

Anti-GABA A Receptor beta 2 antibody - ab186875 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-GABA A Receptor beta 2 antibody (ab186875) at 1/500 dilution + Mouse liver tissue extract

Anti-GABA A Receptor beta 2 antibody - ab123288 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GABA A Receptor beta 2 antibody (ab123288) at 1/100 dilution + A549 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-GABA A Receptor beta 2 antibody [EPR10517] - ab156000 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10517
All lanes : Anti-GABA A Receptor beta 2 antibody [EPR10517] (ab156000) at 1/10000 dilutionLane 1 : HepG2 cell lysateLane 2 : A549 cell lysateLane 3 : Fetal brain lysateLane 4 : Human cerebellum lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-GABRB2 Antibody (aa345-374, PE) - LS-C214522 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRB2 Antibody (aa345-374) - LS-C321524 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRB2 Antibody (aa346-374) - LS-C166327 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GABRB2 Antibody western blot of A549 cell line lysates (35 ug/lane). The GABRB2 antibody detected the GABRB2 protein (arrow).

Anti-GABRB2 Antibody - LS-C341207 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GABRB2 Antibody (aa108-157) - LS-C109989 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GABRB2 antibody LS-C109989 Western blot of 293T cell lysate.

Anti-GABRB2 Antibody (phospho-Ser408/Ser409) - LS-C150362 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRB2 Antibody (Arg431) - LS-C177263 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of GABAA R2 (R431) pAb in paraffin-embedded human brain tissue.

Anti-GABRB2 Antibody (Cytoplasmic Domain) - LS-C244 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of 7 µg of rat cerebellum (Cb) showing specific immunolabeling of the ~55k R2-subunit of the GABAA-R.

Anti-GABRB2 Antibody (phospho-Ser783) - LS-C53454 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of rat synaptic membrane showing specific immunolabeling of the ~102 k GABAB R2 protein phosphorylated at Ser783 (control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: lambda-Ptase). The blot is id

Anti-GABRB2 Antibody (aa80-129) - LS-C205673 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
GABRB2 antibody Western Blot of Fetal Spleen. Antibody dilution: 1 ug/ml.

Anti-GABRB2 Antibody - LS-C331743 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of mouse liver, using GABRB2 antibody.

Anti-GABRB2 Antibody (aa143-192) IHC-plus™ - LS-B954 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GABRB2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B954 concentration 5 ug/ml.

Anti-GABRB2 Antibody - LS-C63384 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GABRB2 Antibody (aa449-462) - LS-C112695 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-GABRB2 Antibody (Cytoplasmic Domain) - LS-C125644 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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