GABRB2

Gene Symbol	GABRB2
Entrez Gene	2561
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	gamma-aminobutyric acid (GABA) A receptor, beta 2
Other Description	GABA(A) receptor subunit beta-2|GABA(A) receptor, beta 2|gamma-aminobutyric acid A receptor beta 2|gamma-aminobutyric acid receptor subunit beta-2
Swissprots	Q16323 D1LYT1 Q4FZB2 P47870 D1LYT0 A8K115 A8K1A0
Accessions	ACY71653 ACY71654 ACY71655 ACY71656 ACY71657 ACY71658 ACY71659 ACY71660 ACY71661 ACY71662 ACY71663 ACY71664 ACY71665 ACY71666 ACY71667 ACY71668 ACY71669 ACY71670 ACY71671 ACY71672 ACY71673 ACY71674 ACY71675 ACY71676 ACY71677 ACY71678 ACY71679 ACY71680 ACY71681 ACY71682 ACY71683 ACY71684 ACY71685 ACY71686 ACY71687 ACY71688 ACY71689 ACY71690 ACY71691 ACY71692 ACY71693 ACY71694 ACY71695 ACY71696 ACY71697 ACY71698 ACY71699 ACY71700 ACY71701 ACY71702 ACY71703 ACY71704 ACY71705 ACY71706 ACY71707 ACY71708 ACY71709 ACY71710 ACY71711 ACY71712 ACY71713 ACY71714 ACY71715 ACY71716 ACY71717 ACY71718 ACY71719 ACY71720 ACY71721 ACY71722 ACY71723 ACY71724 ACY71725 ACY71726 ACY71727 ACY71728 ACY71729 ACY71730 ACY71731 ACY71732 ACY71733 ACY71734 ACY71735 ACY71736 ACY71737 ACY71738 ACY71739 ACY71740 ACY71741 ACY71742 EAW61543 EAW61544 P47870 A28108 CAA01922 AK055125 AK289730 BAF82419 AK289815 BAF82504 AK294437 BAH11765 AK297609 BAH12626 BC036592 BC099705 AAH99705 BC099719 AAH99719 BC105639 AAI05640 GU086163 ACY69094 GU086164 ACY69095 S67368 AAB29370 S77553 AAB33982 S77554 AAB33983 XM_011534501 XP_011532803 NM_000813 NP_000804 NM_021911 NP_068711
Function	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel. {ECO:0000269|PubMed:19763268, ECO:0000269|PubMed:8264558}.
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. {ECO:0000269|PubMed:16983389, ECO:0000269|PubMed:19763268}.
Top Pathways	GABAergic synapse, Morphine addiction, Nicotine addiction, Retrograde endocannabinoid signaling, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GABRB2 overexpression lysate - LY400287 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

GABRB2 overexpression lysate - LY411881 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

GABRB2 overexpression lysate - LY429661 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GABRB2 293 Cell Lysate - 400330 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

GABA-A R beta 2 Overexpression Lysate (Native) - NBL1-10921 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

GABA-A R beta 2 Overexpression Lysate (Native) - NBP2-06504 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

GABRB2 Over-expression Lysate Product - GWB-A18824 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

GABA-A R beta 2 Overexpression Lysate (Native) - NBP2-11262 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human GABRB2 Knockdown Stable Cell Line - CSC-DC006022 from Creative biogene Category Cell Line Species Human

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