| Gene Symbol |
ADIPOR2
|
| Entrez Gene |
79602
|
| Alt Symbol |
ACDCR2, PAQR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adiponectin receptor 2
|
| Other Description |
adiponectin receptor protein 2|progestin and adipoQ receptor family member II
|
| Swissprots |
Q53YY5 Q86V24 Q9H737
|
| Accessions |
CBS99527 EAW88924 Q86V24 AK025085 BAB15062 AK127196 BAC86881 AK128511 BAC87473 AY424280 AAR08368 BC004906 BC051858 AAH51858 BM973815 HQ448616 ADQ33094 XM_005253789 XP_005253846 XM_006719018 XP_006719081 XM_011521024 XP_011519326 XM_011521025 XP_011519327 NM_024551 NP_078827
|
| Function |
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. {ECO:0000269|PubMed:12802337}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:12802337}; Multi-pass membrane protein {ECO:0000269|PubMed:12802337}. Note=Localized to the cell membrane and intracellular organelles.
|
| Tissue Specificity |
Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung. {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:16044242}.
|
| Top Pathways |
Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway
|
![Western Blot: Adiponectin Receptor 2 Overexpression Lysate (Adult Normal) [NBL1-07344] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Adiponectin Receptor 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/18354_Adiponectin%2520Receptor%25202%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07344-img0002.jpg)