IKZF1

Gene Symbol	IKZF1
Entrez Gene	10320
Alt Symbol	Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1
Species	Human
Gene Type	protein-coding
Description	IKAROS family zinc finger 1 (Ikaros)
Other Description	CLL-associated antigen KW-6|DNA-binding protein Ikaros|ikaros family zinc finger protein 1|lymphoid transcription factor LyF-1|protein phosphatase 1, regulatory subunit 92|zinc finger protein, subfamily 1A, 1 (Ikaros)
Swissprots	Q8WVA3 Q53XL2 D3DVM5 A4D260 B4E0Z1 O00598 Q13422 Q69BM4
Accessions	EAL23900 EAL23901 EAW60977 EAW60978 EAW60979 EAW60980 EAW60981 EAW60982 Q13422 AF116605 AAF71030 AF180297 AF432219 AAL99925 AK303586 BAG64603 AK308411 AM085310 CAJ29975 AW337855 AY377974 AAR84585 BC018349 AAH18349 BC064594 BC075820 BF797348 BI767330 BM148203 BT009836 AAP88838 BU537824 BU665456 CA447462 DA944555 DB122945 DB148957 DC391353 HQ448309 ADQ32789 JX459579 AGI59420 S80876 AAB50683 U40462 AAC50459 XM_011515058 XP_011513360 XM_011515059 XP_011513361 XM_011515060 XP_011513362 XM_011515061 XP_011513363 XM_011515062 XP_011513364 XM_011515063 XP_011513365 XM_011515064 XP_011513366 XM_011515065 XP_011513367 XM_011515066 XP_011513368 XM_011515067 XP_011513369 XM_011515068 XP_011513370 XM_011515069 XP_011513371 XM_011515070 XP_011513372 XM_011515071 XP_011513373 XM_011515072 XP_011513374 XM_011515073 XP_011513375 XM_011515074 XP_011513376 XM_011515075 XP_011513377 XM_011515076 XP_011513378 XM_011515077 XP_011513379 XM_011515078 XP_011513380 NM_001220765 NP_001207694 NM_001220767 NP_001207696 NM_001220768 NP_001207697 NM_001220770 NP_001207699 NM_001220771 NP_001207700 NM_001291837 NP_001278766 NM_001291838 NP_001278767 NM_001291839 NP_001278768 NM_001291840 NP_001278769 NM_001291841 NP_001278770 NM_001291842 NP_001278771 NM_001291843 NP_001278772 NM_001291844 NP_001278773 NM_001291845 NP_001278774 NM_001291846 NP_001278775 NM_001291847 NP_001278776 NM_006060 NP_006051 NM_001220766 NM_001220769 NM_001220772 NM_001220773 NM_001220774 NM_001220775 NM_001220776
Function	Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta- globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269
Subcellular Location	Isoform Ik6: Cytoplasm {ECO:0000250}.
Tissue Specificity	Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. {ECO:0000269|PubMed:8543809, ECO:0000269|PubMed:8964602}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ikaros full length protein - ab132325 from Abcam Category Protein Source Wheat germ Species Human

Human Ikaros full length protein - ab169877 from Abcam Category Protein Source E. coli Species Human

Human Ikaros peptide - ab35526 from Abcam Category Peptide

IKZF1 / IKAROS Antibody Blocking Peptide - LS-E118 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKZF1 / IKAROS Antibody Blocking Peptide - LS-E27212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKZF1 / IKAROS Antibody Blocking Peptide - LS-E11523 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKZF1 / IKAROS Antibody Blocking Peptide - LS-E11003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKZF1 / IKAROS Antibody Blocking Peptide - LS-E21148 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IKZF1 / IKAROS Antibody Blocking Peptide - LS-E26368 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Ikaros/IKZF1 Protein - H00010320-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

IKZF1-Antibody-C-term-Blocking-peptide - BP10222b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Ikaros blocking peptide - GTX88298-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Ikaros blocking peptide - GTX88621-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

ikaros Peptide - AC21-1203-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ikaros Peptide - AC21-2033-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

IKZF1 / IKAROS - H00010320-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IKZF1 / IKAROS - H00010320-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IKZF1 Peptide - 42-736P from ProSci Category Peptide Species Human

IKZF1 Peptide - 42-782P from ProSci Category Peptide Species Human

IKZF1 fusion protein - ag2631 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DNA-binding protein Ikaros(IKZF1) - CSB-YP621668HU CSB-EP621668HU CSB-BP621668HU CSB-MP621668HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Ikaros (1-100) - sc-4430 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

IKZF1 / IKAROS - TP313207 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

IKAROS/IKZF1, Peptide - MBS426326 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

IKZF1/IKAROS, Peptide - MBS428023 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

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