IKZF1

Gene Symbol IKZF1
Entrez Gene 10320
Alt Symbol Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1
Species Human
Gene Type protein-coding
Description IKAROS family zinc finger 1 (Ikaros)
Other Description CLL-associated antigen KW-6|DNA-binding protein Ikaros|ikaros family zinc finger protein 1|lymphoid transcription factor LyF-1|protein phosphatase 1, regulatory subunit 92|zinc finger protein, subfamily 1A, 1 (Ikaros)
Swissprots Q8WVA3 Q53XL2 D3DVM5 A4D260 B4E0Z1 O00598 Q13422 Q69BM4
Accessions EAL23900 EAL23901 EAW60977 EAW60978 EAW60979 EAW60980 EAW60981 EAW60982 Q13422 AF116605 AAF71030 AF180297 AF432219 AAL99925 AK303586 BAG64603 AK308411 AM085310 CAJ29975 AW337855 AY377974 AAR84585 BC018349 AAH18349 BC064594 BC075820 BF797348 BI767330 BM148203 BT009836 AAP88838 BU537824 BU665456 CA447462 DA944555 DB122945 DB148957 DC391353 HQ448309 ADQ32789 JX459579 AGI59420 S80876 AAB50683 U40462 AAC50459 XM_011515058 XP_011513360 XM_011515059 XP_011513361 XM_011515060 XP_011513362 XM_011515061 XP_011513363 XM_011515062 XP_011513364 XM_011515063 XP_011513365 XM_011515064 XP_011513366 XM_011515065 XP_011513367 XM_011515066 XP_011513368 XM_011515067 XP_011513369 XM_011515068 XP_011513370 XM_011515069 XP_011513371 XM_011515070 XP_011513372 XM_011515071 XP_011513373 XM_011515072 XP_011513374 XM_011515073 XP_011513375 XM_011515074 XP_011513376 XM_011515075 XP_011513377 XM_011515076 XP_011513378 XM_011515077 XP_011513379 XM_011515078 XP_011513380 NM_001220765 NP_001207694 NM_001220767 NP_001207696 NM_001220768 NP_001207697 NM_001220770 NP_001207699 NM_001220771 NP_001207700 NM_001291837 NP_001278766 NM_001291838 NP_001278767 NM_001291839 NP_001278768 NM_001291840 NP_001278769 NM_001291841 NP_001278770 NM_001291842 NP_001278771 NM_001291843 NP_001278772 NM_001291844 NP_001278773 NM_001291845 NP_001278774 NM_001291846 NP_001278775 NM_001291847 NP_001278776 NM_006060 NP_006051 NM_001220766 NM_001220769 NM_001220772 NM_001220773 NM_001220774 NM_001220775 NM_001220776
Function Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta- globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). {ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490, ECO:0000269|PubMed:17135265, ECO:0000269
Subcellular Location Isoform Ik6: Cytoplasm {ECO:0000250}.
Tissue Specificity Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. {ECO:0000269|PubMed:8543809, ECO:0000269|PubMed:8964602}.

Ikaros (D10E5) Rabbit mAb - 9034 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10E5
Western blot analysis of extracts from various cell lines using Ikaros (D10E5) Rabbit mAb (upper) or β-actin (D6A8) Rabbit mAb #8457 (lower). Western blot results confirm absence of detectable Ikaros protein in HeLa cells, in accordance with the immunofluorescence analysis.

Ikaros Antibody - 5443 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western analysis of extracts from various cell lines using Ikaros Antibody.

Ikaros (E-2) - sc-398265 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ikaros (E-2): sc-398265. Western blot analysis of Ikaros expression in Jurkat (A) and U-937 (B) nuclear extracts and MOLT-4 (C) and Jurkat (D) whole cell lysates.

Ikaros (E-20) - sc-9861 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ikaros (E-20): sc-9861. Western blot analysis of Ikaros expression in U-937 nuclear extract.

Ikaros (H-100) - sc-13039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ikaros (H-100): sc-13039. Western blot analysis of Ikaros expression in non-transfected: sc-110760 (A) and human Ikaros transfected: sc-111057 (B) 293 whole cell lysates.

Ikaros (M-20) - sc-9859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ikaros (M-20): sc-9859. Western blot analysis of Ikaros expression in non-transfected: sc-110760 (A) and human Ikaros transfected: sc-111057 (B) 293 whole cell lysates.

Anti-Ikaros [EPR13790] antibody - ab191394 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13790
All lanes : Anti-Ikaros [EPR13790] antibody (ab191394) at 1/10000 dilutionLane 1 : Raji cell lysateLane 2 : Ramos cell lysateLane 3 : MOLT4 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Ikaros antibody - ab168757 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Ikaros antibody (ab168757) at 1 µg/mlLane 1 : Ikaros-transfected 293T cell line lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-Ikaros antibody - ab106787 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Ikaros antibody (ab106787) at 1 µg/ml + MOLT4 lysate at 35 µg/ml

Anti-Ikaros antibody - ab77411 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-Ikaros antibody (ab77411) at 0.03 µg/ml + MOLT4 cell lysate in RIPA buffer at 35 µg

Anti-Ikaros antibody - ab107194 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Ikaros antibody (ab107194) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-Ikaros antibody [EPR13791] - C-terminal - ab190691 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13791
Immunofluorescent analysis of 4% paraformaldehyde fixed Jurkat cells labeling Ikaros with ab190691 at 1/250 followed by Goat anti rabbit IgG (Alexa Fluor® 555) at 1/200 and conterstained with DAPI.

Anti-Ikaros antibody, prediluted - ab100898 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Staining of Human Ikaros in a Formalin/PFA-fixed paraffin-embedded section of Human Tonsil using ab100898 at a dilution of 1/1.

Anti-Ikaros antibody [SP108] - ab105228 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone SP108
Flow cytometric analysis of rabbit anti-Ikaros (SP108) antibody ab105228 (1/100) in HeLa cells (green) compared to negative control of rabbit IgG (blue).

Anti-Ikaros antibody - N-terminal - ab180713 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling Ikaros with ab180713 at 1/100. Magnification: 400x.

Anti-IKZF1 / IKAROS Antibody (aa43-92) - LS-C151340 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IKZF1 / IKAROS antibody Western Blot of Mouse Heart.

Anti-IKZF1 / IKAROS Antibody - LS-C191414 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IKZF1 / IKAROS Antibody (aa252-301) - LS-C109594 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IKZF1 antibody LS-C109594 Western blot of HeLa lysate.

Anti-IKZF1 / IKAROS Antibody (Internal) - LS-C210126 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-IKZF1 / IKAROS Antibody (aa395-444) - LS-C109710 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
IKZF1 antibody LS-C109710 Western blot of ACHN lysate.

Anti-IKZF1 / IKAROS Antibody (N-Terminus) - LS-C210129 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-IKZF1 / IKAROS Antibody (aa422-452, AP) - LS-C260066 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IKZF1 / IKAROS Antibody (aa422-452, APC) - LS-C260067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IKZF1 / IKAROS Antibody (aa422-452, Biotin) - LS-C260070 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IKZF1 / IKAROS Antibody (aa422-452, FITC) - LS-C260071 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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