| Gene Symbol |
CLCN3
|
| Entrez Gene |
1182
|
| Alt Symbol |
CLC3, ClC-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chloride channel, voltage-sensitive 3
|
| Other Description |
H(+)/Cl(-) exchange transporter 3|chloride channel 3|chloride channel protein 3|chloride transporter ClC-3
|
| Swissprots |
Q86Z21 D3DP34 B7Z932 P51790 O14918 E9PB97 B9EGJ9
|
| Accessions |
EAX04782 EAX04783 EAX04784 EAX04785 EAX04786 P51790 AA780395 AB019542 BAC54560 AF029346 AAB95161 AF086418 AF172729 AAD51034 AK127483 BAG54512 AK304362 BAH14168 AL117599 AM392951 CAL37829 BC026256 BC054877 AAH54877 BC058818 BC136510 AAI36511 BC146697 AAI46698 BP284718 BX647119 DA102505 X78520 CAA55280 XM_005262726 XP_005262783 XM_011531586 XP_011529888 NM_001243372 NP_001230301 NM_001243374 NP_001230303 NM_001829 NP_001820 NM_173872 NP_776297
|
| Function |
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. {ECO:0000269|PubMed:11967229}.
|
| Subcellular Location |
Isoform 1: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Isoform 1 is localized mainly in early and late endosomes.
|
| Tissue Specificity |
Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). {ECO:0000269|PubMed:10198195, ECO:0000269|PubMed:11967229, ECO:0000269|PubMed:12471024}.
|