RAPGEF2

Gene Symbol	RAPGEF2
Entrez Gene	9693
Alt Symbol	CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP
Species	Human
Gene Type	protein-coding
Description	Rap guanine nucleotide exchange factor (GEF) 2
Other Description	PDZ domain containing guanine nucleotide exchange factor (GEF) 1|PDZ domain-containing guanine nucleotide exchange factor 1|RA(Ras/Rap1A-associating)-GEF|cyclic nucleotide ras GEF|neural RAP guanine nucleotide exchange protein|rap guanine nucleotide exchange factor 2|ras/Rap1-associating GEF-1
Swissprots	D3DP27 Q9Y4G8
Accessions	AAY40909 CAF33926 EAX04847 EAX04848 Q9Y4G8 AB002311 BAA20772 AF070570 AK294459 BAG57693 AL117397 CAB55899 BC110355 BC117321 AAI17322 BP386101 BU620827 DA188103 XM_005263358 XP_005263415 XM_005263359 XP_005263416 XM_005263360 XP_005263417 XM_005263361 XP_005263418 XM_006714420 XP_006714483 XM_006714421 XP_006714484 XM_006714422 XP_006714485 XM_011532425 XP_011530727 XM_011532426 XP_011530728 XM_011532427 XP_011530729 NM_014247 NP_055062
Function	Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10608844, PubMed:10548487, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP- induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Provides also inhibitory signals for cell proliferation of melanoma cells and promotes their
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Late endosome. Cell junction {ECO:0000250}. Note=Associated with the synaptic plasma membrane. Colocalizes with ADRB1 at the plasma membrane. Synaptosome. Enriched in synaptic plasma membrane and neuronal cell body. Colocalized with CTNNB1 at cell-cell contacts (By similarity). Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A- dependent manner. Translocated to the cell membrane. {ECO:0000250}.
Tissue Specificity	Expressed in primary neuronal and endocrine cells (at protein level). Highest expression levels in brain. Lower expression levels in heart, kidney, lung, placenta and blood leukocytes. {ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:11168587, ECO:0000269|PubMed:23800469}.
Top Pathways	MAPK signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDZ-GEF1 (Q-15) - sc-168919 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PDZ-GEF1 (T-14) - sc-168920 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-RAPGEF2 antibody - ab56659 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-RAPGEF2 antibody - ab105110 from Abcam Prices $410.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAPGEF2 Antibody (aa541-590) - LS-C135117 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RAPGEF2 Antibody (aa1274-1323) - LS-C201428 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-RAPGEF2 Antibody (aa975-1025) - LS-C286803 from LifeSpan Bioscience Prices $415.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RAPGEF2 Antibody (aa975-1025) - LS-C288727 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2 Antibody - NBP1-06549 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2 Antibody (1E8) - H00009693-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E8

RAPGEF2 Antibody - H00009693-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody - bs-11581R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11581R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11581R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11581R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11581R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, Cy3 Conjugated - bs-11581R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, Cy5 Conjugated - bs-11581R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, Cy5.5 Conjugated - bs-11581R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, Cy7 Conjugated - bs-11581R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, FITC Conjugated - bs-11581R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, Biotin Conjugated - bs-11581R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RAPGEF2/PDZ-GEF1 Polyclonal Antibody, HRP Conjugated - bs-11581R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-RAPGEF2 antibody produced in mouse - WH0009693M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1E8

RAPGEF2 Antibody - C-terminal region (ARP42759_P050) - ARP42759_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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