OTUB1

Gene Symbol	OTUB1
Entrez Gene	55611
Alt Symbol	HSPC263, OTB1, OTU1
Species	Human
Gene Type	protein-coding
Description	OTU deubiquitinase, ubiquitin aldehyde binding 1
Other Description	OTU domain, ubiquitin aldehyde binding 1|OTU domain-containing ubiquitin aldehyde-binding protein 1|OTU-domain Ubal-binding 1|deubiquitinating enzyme OTUB1|otubain-1|ubiquitin thioesterase OTUB1|ubiquitin-specific protease otubain 1|ubiquitin-specific-processing protease OTUB1
Swissprots	Q9P0B8 Q32Q78 Q96FW1 Q9NXQ4 Q96II3
Accessions	CAH05305 EAW74187 EAW74188 EAW74189 EAW74190 EAW74191 Q96FW1 AF161381 AAF28941 AK000120 BAA90956 AK091830 AK098029 BAG53567 AK225133 AK298287 BAG60547 AK303228 BAG64315 AK307413 AL096714 CAH56412 AY177200 AAO27702 BC007519 AAH07519 BC010368 AAH10368 BC107701 AAI07702 CK906312 NM_017670 NP_060140 NR_003089
Function	Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys- 48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OTUB1 (D8F7) Rabbit mAb - 3783 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D8F7

OTUB1 Antibody - 8451 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

OTUB1 (J-61) - sc-130458 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-OTUB1 antibody - ab82154 from Abcam Prices $359.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-OTUB1 antibody - ab101471 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 antibody - ab198214 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OTUB1 antibody - ab76648 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-OTUB1 antibody - ab95998 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-OTUB1 antibody - ab98280 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 antibody [EPR13027(B)] - ab178402 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13027(B)

Anti-OTUB1 antibody [EPR13028(B)] - ab175200 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13028(B)

Anti-OTUB1 / OTU1 Antibody (aa71-120) - LS-C107982 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa35-84) - LS-C111957 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa58-71) - LS-C87302 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa1-40) - LS-C289627 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa40-80) - LS-C289628 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa1-271) - LS-C295739 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa1-271) - LS-C295744 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa1-271, Biotin) - LS-C297384 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (aa1-271, Biotin) - LS-C301114 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-OTUB1 / OTU1 Antibody (clone 1E3) - LS-C337829 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E3

Anti-OTUB1 / OTU1 Antibody (clone 5F7) - LS-C174216 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5F7

Anti-OTUB1 / OTU1 Antibody (clone 2H1) - LS-C174190 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2H1

Anti-OTUB1 / OTU1 Antibody (clone 5B8) - LS-C174183 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5B8

Anti-OTUB1 / OTU1 Antibody (aa1-271, Biotin) - LS-C301151 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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