| Gene Symbol |
FBXO11
|
| Entrez Gene |
80204
|
| Alt Symbol |
FBX11, PRMT9, UBR6, UG063H01, VIT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box protein 11
|
| Other Description |
F-box only protein 11|protein arginine N-methyltransferase 9|ubiquitin protein ligase E3 component n-recognin 6|vitiligo-associated protein 1|vitiligo-associated protein VIT-1
|
| Swissprots |
Q8IXG3 Q53RT5 Q53EP7 Q9H6V8 Q86XK2 Q9UKC2 A1L491 Q9UFK1 Q52ZP1 Q9NR14 Q9H9L1 Q96E90 Q9UHI1
|
| Accessions |
AAY24083 CCQ43404 EAX00202 EAX00203 EAX00204 EAX00205 EAX00206 EAX00207 Q86XK2 AF174599 AAF04520 AF176706 AAF17611 AF264714 AAF76888 AF351618 AAN76518 AI879484 AK022735 BAB14214 AK025477 BAB15143 AK097734 BAG53523 AK223592 BAD97312 AK292877 BAF85566 AK297444 BAG59870 AK304140 BAG65034 AK315108 AL117620 CAB56019 AY827075 AAV87312 BC012728 AAH12728 BC043258 AAH43258 BC130445 AAI30446 BC136480 AAI36481 DN994547 HQ258683 ADR83434 XM_005264572 XP_005264629 XM_005264573 XP_005264630 NM_001190274 NP_001177203 NM_025133 NP_079409 NM_012167 NM_018693
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396}.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Tissue Specificity |
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. {ECO:0000269|PubMed:11775060}.
|
![Western Blot: FBXO11 Overexpression Lysate (Adult Normal) [NBL1-10620] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FBXO11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26230_FBXO11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10620-img0002.jpg)