FBXO11

Gene Symbol FBXO11
Entrez Gene 80204
Alt Symbol FBX11, PRMT9, UBR6, UG063H01, VIT1
Species Human
Gene Type protein-coding
Description F-box protein 11
Other Description F-box only protein 11|protein arginine N-methyltransferase 9|ubiquitin protein ligase E3 component n-recognin 6|vitiligo-associated protein 1|vitiligo-associated protein VIT-1
Swissprots Q8IXG3 Q53RT5 Q53EP7 Q9H6V8 Q86XK2 Q9UKC2 A1L491 Q9UFK1 Q52ZP1 Q9NR14 Q9H9L1 Q96E90 Q9UHI1
Accessions AAY24083 CCQ43404 EAX00202 EAX00203 EAX00204 EAX00205 EAX00206 EAX00207 Q86XK2 AF174599 AAF04520 AF176706 AAF17611 AF264714 AAF76888 AF351618 AAN76518 AI879484 AK022735 BAB14214 AK025477 BAB15143 AK097734 BAG53523 AK223592 BAD97312 AK292877 BAF85566 AK297444 BAG59870 AK304140 BAG65034 AK315108 AL117620 CAB56019 AY827075 AAV87312 BC012728 AAH12728 BC043258 AAH43258 BC130445 AAI30446 BC136480 AAI36481 DN994547 HQ258683 ADR83434 XM_005264572 XP_005264629 XM_005264573 XP_005264630 NM_001190274 NP_001177203 NM_025133 NP_079409 NM_012167 NM_018693
Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396}.
Subcellular Location Nucleus. Chromosome.
Tissue Specificity Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes. {ECO:0000269|PubMed:11775060}.

FBXO11 CRISPR/Cas9 KO Plasmid (h) - sc-418142 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 HDR Plasmid (h) - sc-418142-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 Double Nickase Plasmid (h) - sc-418142-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 Double Nickase Plasmid (h2) - sc-418142-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 CRISPR Activation Plasmid (h) - sc-418142-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 CRISPR Activation Plasmid (h2) - sc-418142-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 Lentiviral Activation Particles (h) - sc-418142-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 Lentiviral Activation Particles (h2) - sc-418142-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBXO11 siRNA (h) - sc-94892 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXO11 shRNA Plasmid (h) - sc-94892-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXO11 shRNA (h) Lentiviral Particles - sc-94892-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXO11 RNAi - H00080204-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FBXO11 RNAi - H00080204-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU025931 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8533 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8533 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FBXO11 siRNA (Human) - CRJ2798 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXO11 RNAi - H00080204-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FBXO11 - MBS8222982 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBXO11 (NM_001190274.1) - SHH293037 from Creative biogene

Category siRNA
Species Reactivities Human

FBXO11 shRNA Plasmid (Human) - CHJ2798 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBXO11 miRNA 3'UTR clone - MiUTR3H-09520 from Creative biogene

Species Reactivities Human
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